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Specific antibody deficiency in children with chronic wet cough
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  • Published on:
    Re:Specific antibody deficiency in children with chronic wet cough

    Lim et al(1) understandably interpret the results of their retrospective study with caution. However they only consider one possible chain of causation in seeking to explain their findings, namely that children with worse chest radiographs who made poorer antibody responses did so as a consequence of an underlying primary immunodeficiency. An alternative explanation would be that previous, chronic lower and/or upper resp...

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    Conflict of Interest:
    None declared.
  • Published on:
    The importance of thorough investigation of children with chronic wet cough
    • Malcolm Brodlie, Academic Clinical Lecturer
    • Other Contributors:
      • Terry Flood and David A Spencer

    Dear Editor,

    We read with interest the recent paper by Lim et al. reporting the prevalence of specific polysaccharide antibody deficiency in a cohort of 96 children with chronic wet cough.[1] Specific polysaccharide antibody deficiency was defined in terms of inadequate pneumococcal serotype- specific antibody levels following immunisation with Prevenar and/or Pneumovax II. Results of other immunological investi...

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    Conflict of Interest:
    None declared.