Online First

September 30, 2022

September 28, 2022

  • Editorial
    There’s science… and then there might be policy change…
    C Ronny Cheung, Nick Brown
  • Original research
    Successful integration of newborn genetic testing into UK routine screening using prospective consent to determine eligibility for clinical trials
    Owen Martyn Bendor-Samuel, Tabitha Wishlade, Louise Willis, Parvinder Aley, Edward Choi, Rachel Craik, Yama Mujadidi, Ginny Mounce, Fenella Roseman, Arancha De La Horra Gozalo, James Bland, Nazia Taj, Ian Smith, Anette-Gabriele Ziegler, Ezio Bonifacio, Christiane Winkler, Florian Haupt, John A Todd, Laurent Servais, Matthew D Snape, Manu Vatish the GPPAD Study Group

    This study looked at the use of prospective consent for participation in a study using the newborn screening blood spot to evaluate a genetic risk score for Type 1 Diabetes. This score was used to identify individuals who were offered an opportunity to participate in an interventional trial. The methodology provides a model for future clinically relevant population based genetic research.

  • Drug therapy
    Use of xylometazoline in hospitalised infants: is it safe? A retrospective cohort study
    Karlijn J van Stralen, Joyce E van Tol, Saskia N de Wildt, Matthijs L Becker, Marlies A van Houten

    Xylometazoline spray or drops were evaluated for safety when used for nasal decongestion in infants less than 2 years of age in a Dutch study - and the study concludes they appear to be safe.

September 27, 2022

September 26, 2022

  • Original research
    Influence of epidemics and pandemics on paediatric ED use: a systematic review
    Damian Roland, Adam Gardiner, Darakhshan Razzaq, Katy Rose, Silvia Bressan, Kate Honeyford, Danilo Buonsenso, Liviana Da Dalt, Tisham De, Ruth Farrugia, Niccolo Parri, Rianne oostenbrink, Ian K Maconochie, Zsolt Bognar, Henriette A Moll, Luigi Titomanlio, Ruud Gerard Gerard Nijman in association with the REPEM network (Research in European Paediatric Emergency Medicine) as part of the EPISODES Study

    Through a systematic review, the authors assessed the impact of epidemics and pandemics on the utilisation of paediatric emergency care services, and found that epidemics have profound but extremely variable effects.

  • Original research
    Impact of different nebulisation systems on patient comfort in bronchiolitis: a randomised controlled cross-over trial
    Juan Valencia-Ramos, Carlos Ochoa Sangrador, María García, Pablo Oyagüez, Juan Arnaez

    There is currently little evidence of clinical benefit for the use of nebulized therapy for bronchiolitis. In this study nebulization via high flow nasal cannulae was better tolerated than a traditional jet nebulization system. Thus, there may be an opportunity to revaluate clinical efficacy of nebulized therapy using a better tolerated system.

September 13, 2022

September 09, 2022

September 07, 2022

  • Global child health
    Incidence and aetiology of infant Gram-negative bacteraemia and meningitis: systematic review and meta-analysis
    Luisa K Hallmaier-Wacker, Amelia Andrews, Olisaeloka Nsonwu, Alicia Demirjian, Russell J Hope, Theresa Lamagni, Simon M Collin

    This systematic review confirms the disproportionate burden of Gram negative infections in low and middle income countries, compared to high income countries.

  • Global child health
    Sickle cell disease in children: an update of the evidence in low- and middle-income settings
    Isaac Odame

    Systematic review of the management of sickle cell disease in low and middle income countries. It is both an excellent commentary of the state of this disease in high and low income settings, and up-to-date guideline for treating sickle cell disease in all settings

  • Global child health
    Vitamin D deficiency in South-East Asian children: a systematic review
    Vicka Oktaria, Dwi Astuti Dharma Putri, Zulfikar Ihyauddin, Madarina Julia, Dian Caturini Sulistyoningrum, Poh Bee Koon, Margaret Danchin, Indah Kartika Murni

    Vitamin D deficiency remains underdiagnosed worldwide, with significant impacts on many aspects of child health. The high rates of seemingly healthy children in southeast Asia commonly suffering from this condition help bring attention to this hidden form of malnutrition.

  • Global child health
    Training packages for the use of child development tools in low/middle-income countries: a review
    Maria Neocleous, Katelyn Hepworth, Vanessa Cavallera, Melissa Gladstone

    Essential to improvements in overall child health is an emphasis on helping children thrive as well as survive. This new emphasis will require a well-trained healthcare workforce in this regard. This paper reviews child development training packages in resource-limited settings.

September 06, 2022

  • Original research
    Robustness of reported postacute health outcomes in children with SARS-CoV-2 infection: a systematic review
    Julian Hirt, Perrine Janiaud, Viktoria Luise Gloy, Stefan Schandelmaier, Tiago V Pereira, Despina Contopoulos-Ioannidis, Steven N Goodman, John Ioannidis, Klaus Munkholm, Lars G Hemkens
  • Global child health
    Enhancing respiratory disease diagnosis by bronchoalveolar lavage in Kashmir: an audit of findings
    Javeed Iqbal Bhat, Zubair M Tramboo, Tajamul Hussain Shah, Bashir Ahmad Charoo, Iqbal Ahmad Qazi

    In Low and Middle Income Countries, diagnosis of respiratory disease in the absence of sophisticated microbiology is often difficult. This study from Kashmir illustrates how, logistically feasible, bronchoalveolar lavage can enhance both time and validity of investigation.

  • Paediatric Emergency Medicine
    Rate of invasive bacterial infection in recently vaccinated young infants with fever without source
    Ana Barreiro-Parrado, Eider Lopez, Borja Gomez, Ainara Lejarzegi, Amaia Fernandez-Uria, Javier Benito, Santiago Mintegi

    This secondary analysis of observational registry data compared the rates of IBI (bacterial pathogen in blood or cerebrospinal fluid) and urinary tract infection (UTI) in febrile infants between 42 and 90 days of age who had and had not been vaccinated in the previous 48 hours and conclude that UTI screening remains appropriate, but with further study the need for IBI screening in recently vaccinated infants could be revisited.

September 05, 2022

  • Original research
    Diagnostic test accuracy of dipstick urinalysis for diagnosing urinary tract infection in febrile infants attending the emergency department
    Thomas Waterfield, Steven Foster, Rebecca Platt, Michael J Barrett, Sheena Durnin, Julie-Ann Maney, Damian Roland, Lisa McFetridge, Hannah Mitchell, Etimbuk Umana, Mark D Lyttle On behalf of Paediatric Emergency Research in the UK and Ireland (PERUKI)

    This retrospective cohort study aimed to assess the diagnostic test accuracy of dipstick urinalysis for the detection of urinary tract infections in febrile infants (<90 days) in the ED. The authors found that point-of-care urinalysis is moderately sensitive and highly specific for diagnosing UTI in this population.

September 02, 2022

August 30, 2022

August 26, 2022

August 25, 2022

August 23, 2022

August 12, 2022

August 11, 2022

August 10, 2022

August 08, 2022

August 05, 2022

July 28, 2022

July 26, 2022

July 22, 2022

July 21, 2022

July 20, 2022

  • Original research
    Community seroprevalence of SARS-CoV-2 in children and adolescents in England, 2019–2021
    Helen Ratcliffe, K S Tiley, Nick Andrews, Gayatri Amirthalingam, I Vichos, E Morey, N L Douglas, S Marinou, Emma Plested, Parvinder Aley, Eva P Galiza, Saul N Faust, S Hughes, Clare S Murray, Marion Roderick, Fiona Shackley, Sam J Oddie, Tim Lees, D P J Turner, M Raman, Stephen Owens, Paul Turner, H Cockerill, J Lopez Bernal, E Linley, Ray Borrow, Kevin Brown, Mary Elizabeth Ramsay, M Voysey, Matthew D Snape

    How many children have antibody to COVID-19 before they are vaccinated? This community seroprevalance study finds about a third of children with antibody to COVID (although this varies by age and ethnicity). In children <10-years there were no symptoms or symptom clusters that reliably predicted seropositivity.

July 19, 2022

  • Images in paediatrics
    Unusual cause of ‘croup’
    Emily Pye, Charlotte Lucy Durand, Anne Kerr, Adam J Donne

July 18, 2022