Online First

October 14, 2021

October 08, 2021

October 07, 2021

October 05, 2021

  • Original research
    Friedreich’s ataxia-associated childhood hypertrophic cardiomyopathy: a national cohort study
    Gabrielle Norrish, Thomas Rance, Elena Montanes, Ella Field, Elspeth Brown, Vinay Bhole, Graham Stuart, Orhan Uzun, Karen A McLeod, Maria Ilina, Satish Adwani, Piers Daubeney, Grazia Delle Donne, Katie Linter, Caroline B Jones, Tara Bharucha, Elena Cervi, Juan Pablo Kaski

    In the largest cohort of children with Hypertrophic Cardiomyopathy associated with Friedrich's Ataxia presented to date a surprisingly high prevalence of atrial arrhythmias are described, and a reminder of the need for serial cardiac screening in these children is reinforced.

October 01, 2021

September 29, 2021

September 28, 2021

September 27, 2021

  • Original research
    Dosing of enteral acetaminophen in critically ill children: a cohort study
    Nadia Roumeliotis, Helena Frndova, Eleanor Pullenayegum, Anna Taddio, Paula Rochon, Christopher S Parshuram

    Prescribing paracetamol is one of the most common therapeutic interventions in hospitals. This large retrospective study review when under- and over-dosing occurs in children in PICU, and finds age, cardiac admission are significant risk factors.

  • Editorial
    Clinical ethics: consent for vaccination in children
    Dominic Wilkinson, Antonia Kathryn Sarah McBride

September 22, 2021

September 21, 2021

September 20, 2021

  • Original research
    Inconsistencies in fertility preservation for young people with cancer in the UK
    Hannah L Newton, Helen M Picton, Amanda Jane Friend, Catherine M Hayden, Mark Brougham, Rachel Cox, Victoria Grandage, Michelle Kwok-Williams, Sheila Lane, Rod Thomas Mitchell, Roderick Skinner, W Hamish Wallace, Daniel Yeomanson, Adam W Glaser on behalf of the Children’s Cancer and Leukaemia Group Late-effects Working Group

    This study highlights marked variation in provision and funding of fertility preservation services for children with cancer across the UK. Based on these findings, the authors argue that centralised NHS funding should be made available to ensure equitable provision of fertility preservation services and delivery of internationally acknowledged quality standards to all young people with cancer across the UK.

September 17, 2021

  • Review
    Exercise training in paediatric congenital heart disease: fit for purpose?
    Nurul Hidayah Amir, Dan M Dorobantu, Curtis A Wadey, Massimo Caputo, A. Graham Stuart, Guido E Pieles, Craig A Williams
  • Original research
    Categorising high-cost high-need children and young people
    Nikita Punjabi, Kathryn Marszalek, Thomas Beaney, Rakhee Shah, Dasha Nicholls, Sarah Deeny, Dougal Hargreaves

    A retrospective observational clinical database study shows the top 5% of CYP (high-cost high-need patients) account for more than half of our annual spending for CYP, largely driven by inpatients. The most common diagnoses are mental health, metabolic, respiratory, neurological conditions.

September 16, 2021

September 15, 2021

  • Global child health
    Barriers to seeking timely treatment for severe childhood pneumonia in rural Bangladesh
    Kamal Ibne Amin Chowdhury, Ishrat Jabeen, Mahfuzur Rahman, Abu Syed Golam Faruque, Nur H Alam, Shahjahan Ali, Tahmeed Ahmed, George J Fuchs, Trevor Duke, Niklaus Gyr, Haribondhu Sarma

    Lower respiratory illness remains the largest cause of mortality for children under 5 worldwide. Early intervention and care can be profoundly lifesaving, but significant barriers to seeking care remain. In this qualitative study, several are identified among Bangladeshi mothers.

  • Editorial
    Varying international practices regarding the evaluation of febrile young infants
    Etimbuk Umana, Thomas Waterfield
  • Original research
    Factors associated with severe respiratory syncytial virus disease in hospitalised children: a retrospective analysis
    Jeremy Anderson, Michelle Oeum, Eva Verkolf, Paul V Licciardi, Kim Mulholland, Cattram Nguyen, Kim Chow, Gregory Waller, Anna-Maria Costa, Andrew Daley, Nigel W Crawford, Franz E Babl, Trevor Duke, Lien Anh Ha Do, Danielle Wurzel

    Respiratory syncytial virus (RSV) disease places a large burden on healthcare systems. Early recognition of children at risk of severe RSV disease may be useful. This study finds younger age (<2 months) and prematurity are associated with increased severity of RSV disease. An association between Para-influenza virus type 3/RSV co-detection and severe disease may warrant further investigation.

  • Global child health
    Pertussis seroprevalence in mother–infant pairs from India: role of maternal immunisation
    Rajlakshmi Viswanathan, Sanjay Bafna, Kalyani Patil, Santoshkumar Jadhav, Savita Katendra, Shweta Mishra, Shradha Maheshwari, Hemant Damle

    This observational study showed that in one location in India, pertussis immunity among pregnant women was low (12%) pertussis immunization in early pregnancy resulted in a higher proportion (54%) of mothers and newborns with pertussis antibodies at a protective level. The appropriate timing of maternal immunization is discussed.

September 14, 2021

September 11, 2021

  • Global child health
    Neurodevelopment in normocephalic children with and without prenatal Zika virus exposure
    Karen Blackmon, Roberta Evans, Michelle Fernandes, Barbara Landon, Trevor Noel, Calum Macpherson, Nikita Cudjoe, Kemi S Burgen, Bianca Punch, Amy Krystosik, Elysse N Grossi-Soyster, Angelle Desiree LaBeaud, Randall Waechter

    A follow up study of infants born to mothers with pregnancy exposure to Zika virus showed infants who had been exposed to Zika virus but who had a normal head circumference had overall normal development, but all such Zika virus infants should undergo formal visual testing.

September 05, 2021

September 03, 2021

September 02, 2021

  • Original research
    School academic performance of children hospitalised with a chronic condition
    Nan Hu, Joanna Fardell, Claire E Wakefield, Glenn M Marshall, Jane C Bell, Natasha Nassar, Raghu Lingam

    This population-based cohort study using health administrative data examined academic performance in children with chronic conditions who were hospitalised. Compared to children who were not hospitalised, children hospitalized with a chronic condition underperformed in literacy and numeracy domains in grades 3, 5, and 7. A greater number of bed days or hospitalisations was associated with poorer academic performance.

August 30, 2021

August 26, 2021

August 25, 2021

  • Original research
    Examining the interseasonal resurgence of respiratory syncytial virus in Western Australia
    David Anthony Foley, Linny Kimly Phuong, Joseph Peplinski, Selina Mei Lim, Wei Hao Lee, Asifa Farhat, Cara A Minney-Smith, Andrew C Martin, Ariel O Mace, Chisha T Sikazwe, Huong Le, Avram Levy, Tobias Hoeppner, Meredith L Borland, Briony Hazelton, Hannah C Moore, Christopher Blyth, Daniel K Yeoh, Asha C Bowen

    Lockdowns associated with the COVID-19 pandemic have led to an unusual epidemiology for common childhood respiratory pathogens. In this paper, the epidemiology and clinical characteristics of summertime RSV infection in Western Australia are described.

  • Viewpoint
    Three generations of paediatric training
    Lionel P Balfour-Lynn, Rosie E Balfour-Lynn, Ian M Balfour-Lynn
  • Letter
    Management of anaphylaxis in children undergoing oral food challenges in an adapted COVID-19 field hospital
    Ali Al Saleemi, Linda Farren, Kevin F McCarthy, Jonathan Hourihane, Aideen M Byrne, Juan Trujillo, Cathryn O’Carroll, Mohammed Tariq, John J Fitzsimons, David Coghlan

August 24, 2021

  • Letter
    Impact of clinical and patient pathway changes on paediatric research during the national COVID-19 response
    Pamela Dicks, Jürgen Schwarze, Paul Dimitri
  • Original research
    Lead screening in children presenting to three hospitals in Lebanon
    Tharwat El Zahran, Hala Mostafa, Hani Hamade, Moustafa Al Hariri, Aed Saab, Hani Tamim, Rasha Tohme, Dany A Al Hamod, Durriyah Sinno, Rasha Dorothy Sawaya, Ziad Kazzi

    This study in three hospitals in Lebanon studied blood lead levels in 90 children the mean blood lead level was 1.05 μg/dL. All values were below 5.0 μg/dL, a marked decrease compared to before a national ban on leaded gasoline in 2002. The study identified risk factors for higher blood lead levels, including living in a house aged 40 years or more, receiving traditional remedies, and a lower household income.

August 23, 2021

August 20, 2021