Online First

June 22, 2021

  • Original research
    Shock Index in the early assessment of febrile children at the emergency
    Nienke N Hagedoorn, Joany M Zachariasse, Dorine Borensztajn, Elise Adriaansens, Ulrich von Both, Enitan D Carrol, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Jethro Adam Herberg, Benno Kohlmaier, Emma Lim, Ian Maconochie, Federico Martinón-Torres, Ruud Gerard Nijman, Marko Pokorn, Irene Rivero-Calle, Maria Tsolia, Dace Zavadska, Werner Zenz, Michael Levin, Clementien Vermont, Henriette A Moll On behalf of the PERFORM consortium

    EU multicentre ED study of presenting vital signs in >5000 febrile children with an association between "shock index" and serious illness, but low sensitivity limits utility in screening.

  • Short report
    Delivering tertiary tuberculosis care virtually
    Louise Turnbull, Christine Bell, Stefanie Davies, Fran Child

    A weekly virtual clinic with MDT discussion between between district paediatricians and a tertiary TB team showed that:45% children received care closer to home. Median time from presentation to treatment reduced by 28%. 21% more children diagnosed before developing symptoms.

June 21, 2021

June 17, 2021

  • Letter
    Ethiopian paediatric oncology registry progress report: documentation practice improvements at tertiary care centre in Addis Ababa, Ethiopia
    Scott Levy, Atalay Mulu Fentie, Kaitlyn Buhlinger, Stephen M Clark, David N Korones, Vanessa Miller, Thomas B Alexander, Sheila Weitzman, Wondwessen Bekele, Julie Broas, Aziza Shad, Megan Roberts, Michael Chargualaf, Diriba Fufa, Tadele Hailu, Mulugeta Ayalew Yimer, Mohammed Mustefa, Abdulkadir M Said Gidey, Ali Mamude Dinkiye, Haileyesus Adam, Daniel Hailu, Benyam Muluneh
  • Clinical law for clinical practice
    Providing beds for children
    Robert Wheeler
  • Original research
    Impaired grip strength in children with congenital heart disease
    Michael Meyer, Yi Wang, Leon Brudy, Anna-Luisa Häcker, Thorsten Schulz, Heidi Weberruss, Renate Oberhoffer, Peter Ewert, Jan Müller

    Physical fitness is an important aspect of wellness. In 569 long term survivors of CHD surgery both grip strength & health-related physical fitness (a 5 parameter composite) were reduced but the reductions were unrelated. Grip strength is easily assessed but is not a surrogate for the more complex tool.

  • Original research
    Listeria infection in young infants: results from a national surveillance study in the UK and Ireland
    Stefania Vergnano, Gauri Godbole, Ameze Simbo, Alison Smith-Palmer, Martin Cormican, Mark Anthony, Paul T Heath

    Who needs empirical treatment for Listeria infection? This national surveillance study found that invasive listeriosis in young infants in the UK and Ireland is rare and presented only in the neonatal period. Use of amoxicillin as part of empiric treatment for sepsis and meningitis in infants over 1 month of age may be unnecessary.

June 16, 2021

  • Original research
    Prevalence of monogenic disease in paediatric patients with a predominant respiratory phenotype
    Dan Dai, Mei Mei, Liyuan Hu, Yun Cao, Xiaochuan Wang, Libo Wang, Yulan Lu, Lin Yang, Xinran Dong, Huijun Wang, Bingbing Wu, Liling Qian

    This manuscript reports on the prevalence and clinical characteristics of monogenic disease in paediatric patients with a predominant respiratory phenotype. And that exam sequencing is a valuable tool for this with 140 positive cases in a cohort of 971.

June 14, 2021

  • Editorial
    Gestational age and birth before 40 weeks of gestation
    Neil Marlow
  • Original research
    Impact of genetic tests on survivors of paediatric sudden cardiac arrest
    Shuenn-Nan Chiu, Jyh-Ming Jimmy Juang, Wei-Chieh Tseng, Wen-Pin Chen, Ni-Chung Lee, Mei-Hwan Wu

    Sudden cardiac death / resuscitated survival is rare and distressing, with implications for siblings and parents too. In 32 Taiwanese survivors of SCD with previously negative gene testing, state-of-the-art composite genetic panel testing provided new, useful information for 85%. Test, now and test again later.

June 10, 2021

  • Review
    Use of rituximab in paediatric nephrology
    Rajiv Sinha, Nirav Agrawal, Yuanxin Xue, Rahul Chanchlani, Subal Pradhan, Rupesh Raina, Stephen D Marks

    This review provides a comprehensive overview of the B-cell depleting monoclonal antibody rituximab and its efficacy in the treatment of various immune mediated renal diseases and after transplantation. It describes major indications and addresses open questions and missing data.

June 03, 2021

May 27, 2021

  • Viewpoint
    Legacy of COVID-19 infection in children: long-COVID will have a lifelong health/economic impact
    Daniel Munblit, Frances Simpson, Jeremy Mabbitt, Audrey Dunn-Galvin, Calum Semple, John O Warner
  • Original research
    New-onset type 1 diabetes in Finnish children during the COVID-19 pandemic
    Heli Salmi, Santtu Heinonen, Johanna Hästbacka, Mitja Lääperi, Paula Rautiainen, Päivi J Miettinen, Olli Vapalahti, Jussi Hepojoki, Mikael Knip

    A Finnish retrospective cohort study of two datasets: children with Type 1 diabetes (T1D) admitted to PICU and children with T1D registered to the Finnish Pediatric Diabetes Registry. They found that more children with T1D had severe DKA at diagnosis during the pandemic. This stems from delay in presentation and diagnosis rather than a consequence of SARS-CoV-2 infection.

May 25, 2021

May 24, 2021

May 20, 2021

May 14, 2021

May 12, 2021

May 11, 2021

  • Letter
    Foreign body ingestion in children: a magnet epidemic within a pandemic
    Hemanshoo Thakkar, Katherine Mary Burnand, Costa Healy, Erica Makin, Joseph Davidson, George Bethell, Hesham Elagami, Alexandra Scarlett, Shabnam Parkar, Manasvi Upadhyaya, Iain Yardley On behalf of the Quadri-South East Paediatric Surgeons (QuadriSEPS) Group
  • Original research
    Novel strategy to personalise use of ibuprofen for closure of patent ductus arteriosus in preterm neonates
    Samira Samiee-Zafarghandy, Tamara van Donge, Gerhard Fusch, Marc Pfister, George Jacob, Andrew Atkinson, Michael J Rieder, Cornelis Smit, John Van Den Anker

    This study examines the pharmacokinetics of ibuprofen given to neonates for patent ductus arteriosus closure. Low concentrations of ibuprofen can be identified, which moves studies comparing individualised dosing a step closer.

  • Review
    Paediatric narcolepsy: a review of diagnosis and management
    Jane Elizabeth Blackwell, Ruth N Kingshott, Anna Weighall, Heather E Elphick, Hannah Nash

    The authors present a comprehensive review of narcolepsy in childhood, including details on our current understanding of pathophysiology, how to investigate a child when a diagnosis is suspected and suggestions for management.

May 07, 2021

May 06, 2021

  • Original research
    Medication discrepancies in transition of care of hospitalised children in Brazil: a multicentric study
    Giulyane Targino Aires-Moreno, Thaciana dos Santos Alcântara, Dyego Carlos Souza Anacleto de Araújo, Simony da Mota Soares, Vanessa Terezinha Gubert, Vanessa Marcon de Oliveira, Cristiane Munaretto Ferreira, Erica Freire Vasconcelos-Pereira, Ana Rafaela Pires Lira, Clarice Chemello, Layse Maria Soares de Oliveira, Alfredo Dias de Oliveira-Filho, Divaldo Lyra Jr

    Accurate medication reconciliation is important, and this 4 centre study from Brasil shows the prevalence and significance of omissions, both unintentional and intentional.

  • Review
    Bibliography of published COVID-19 in children literature
    Philippa Anna Stilwell, Alasdair P. S. Munro, Emre Basatemur, Nishanthi Talawila Da Camara, Rachel Harwood, Damian Roland

    A paper that describes the dynamic changes in global volume of literature relating to Covid-19 in children and young people published over the first six months of the pandemic. Two thirds of all papers published described just nine patients or fewer.

May 05, 2021

May 03, 2021

April 30, 2021

April 27, 2021

April 21, 2021

  • Original research
    Intimate partner violence and child outcomes at age 10: a pregnancy cohort
    Deirdre Gartland, Laura J Conway, Rebecca Giallo, Fiona K Mensah, Fallon Cook, Kelsey Hegarty, Helen Herrman, Jan Nicholson, Sheena Reilly, Harriet Hiscock, Emma Sciberras, Stephanie J Brown

    In an Australian pregnancy cohort, maternal report of intimate partner violence is associated with poorer physical and mental health outcomes for their children at age 10 years.

April 20, 2021

April 16, 2021

  • Original research
    Feeding disorders in children with oesophageal atresia: a cross-sectional study
    Aurélie Pham, Emmanuelle Ecochard-Dugelay, Arnaud Bonnard, Enora Le Roux, Thomas Gelas, Véronique Rousseau, Nadège Thomassin, Isabelle Cabon-Boudard, Audrey Nicolas, Audrey Guinot, Julie Rebeuh, Aurélie Le Mandat, Djamal-Dine Djeddi, Virginie Fouquet, Aurélie Boucharny, Sabine Irtan, Julie Lemale, Aurélie Comte, Laure Bridoux-Henno, Claire Dupont-Lucas, Georges Dimitrov, Anne Turquet, Corinne Borderon, Cécile Pelatan, Emilie Chaillou Legault, Camille Jung, Stéphanie Willot, Louise Montalva, Delphine Mitanchez, Frederic Gottrand, Marc Bellaiche

    This study of patients from the French national network oesophageal atresia (OA) registry used a standardised questionnaire to investigate the frequency of feeding disorders. These were diagnosed in 42%, of whom over a third had failed to thrive. The authors advocate systematic feeding assessment in follow up of children operated on for OA.

April 15, 2021

April 14, 2021

  • Review
    Cystic fibrosis transmembrane conductance regulator modulators for cystic fibrosis: a new dawn?
    Claire Edmondson, Christopher William Course, Iolo Doull

    Until recently, progress in the management of cystic fibrosis, had been limited by the lack of means of modifying the root cause, the function of the CF transmembrane regulator. Since the arrival of ivacaftor and it related modulators, potential long term outcomes have been enhanced, though cost is currently a barrier to wider routine intervention to the 90 % of children likely to benefit.