We thank Professor Wright for her comments, and we welcome the opportunity to provide some clarification and further analysis.
We reported Z-scores rather than percentiles, although some comments on approximate percentiles can be made. Assuming that Z scores of -1.96 and -3 represent approximately the 2.5th and 0.2nd centiles respectively, 36/101 children were below the 2.5th centile, and 17/101 were below the 0.2nd centile for weight. Additionally, our mixed effects model (accounting for multiple measurements) modelling the group trend over time estimated the mean weight Z score at 11 years to be -1.63 (approximately 5th centile).
Despite the overall short stature of the group, 24/101 children had a BMI Z score of less than -1.96. So, by this approach, their weight was low even after taking into account stature. We agree that we cannot infer causality from this observational study, but we believe a proportion of the stunted growth is explained by low weight. We are exploring other measures of malnutrition, such as skin-fold thickness.
Whilst our patient numbers are small, they do give some weight to the argument that PEG feeding halts the progression of malnutrition. We investigated the rate of decline of weight after PEG insertion. In a mixed effects model with a random intercept for individual patients, the rate of wei...
We thank Professor Wright for her comments, and we welcome the opportunity to provide some clarification and further analysis.
We reported Z-scores rather than percentiles, although some comments on approximate percentiles can be made. Assuming that Z scores of -1.96 and -3 represent approximately the 2.5th and 0.2nd centiles respectively, 36/101 children were below the 2.5th centile, and 17/101 were below the 0.2nd centile for weight. Additionally, our mixed effects model (accounting for multiple measurements) modelling the group trend over time estimated the mean weight Z score at 11 years to be -1.63 (approximately 5th centile).
Despite the overall short stature of the group, 24/101 children had a BMI Z score of less than -1.96. So, by this approach, their weight was low even after taking into account stature. We agree that we cannot infer causality from this observational study, but we believe a proportion of the stunted growth is explained by low weight. We are exploring other measures of malnutrition, such as skin-fold thickness.
Whilst our patient numbers are small, they do give some weight to the argument that PEG feeding halts the progression of malnutrition. We investigated the rate of decline of weight after PEG insertion. In a mixed effects model with a random intercept for individual patients, the rate of weight Z score decline was 0.01 units per year, in contrast with 0.1 per year in the un-operated population, although low numbers prevent a meaningful statistical comparison. Given the ultra-rare nature of the disease, a randomised trial is effectively impossible and probably anyway unethical.
The multifactorial aetiology of wasting is unique in A-T. The disease compromises varying components of chronic inflammation, poor feeding ability, and increased calorie consumption due to dystonic and athetoid movements. The prognosis in A-T is truly appalling, and therefore we aim for the best possible quality of life. As well as showing that PEG feeding halts the progression of malnutrition (albeit in small numbers of children as compared to controls) and making feeding safer in the presence of possible aspiration, one consistent theme (not reported in our paper but consistently reported by parents in our clinic and previously published by other groups(1)) is significant caregiver satisfaction and reduction in very lengthy meals times. This has a very significant impact in improving the quality of life of carers and patients.
It is well recognised in other chronic paediatric diseases, such as cystic fibrosis and chronic kidney disease that nutrition is a predictor of overall quality of life. Currently, we have very little to offer patients with A-T in terms of intervention to prevent the development of malignancy or neurological progression, but we believe by extrapolating from other similar patient groups, we can reduce the risk of death from pulmonary failure. Key to this is prevention of wasting.
All long term invasive medical technologies interfere with the human condition of childhood, and we wholeheartedly agree that a PEG is life-changing and should always be carefully considered on an individual basis. However, given the poor weight gain in many A-T children, we believe it is important to discuss whether a PEG would be useful early, and consider placement prior to the respiratory deterioration of the child.
Yours sincerely
Emma Stewart1, Andrew P Prayle2, Alison Tooke1, Sara Pasalodos3, Mohnish Suri3, Andy Bush4,5,6, Jayesh M Bhatt1
Author affiliations:
1 Nottingham Children's Hospital, National Paediatric Ataxia Telangiectasia Clinic, QMC, Nottingham, UK
2 University of Nottingham, School of Clinical Science, Queens Medical Centre, Child Health, Nottingham, UK
3 Nottingham Clinical Genetics Service, National Paediatric Ataxia Telangiectasia Clinic, Clinical Genetics Service, City Hospital Campus, Nottingham, UK
4 Imperial College, London, UK
5 National Heart and Lung Institute, London, UK
6 Royal Brompton & Harefield NHS Foundation Trust, London, UK
1. Lefton-Greif MA, Crawford TO, McGrath-Morrow S, Carson KA, Lederman HM. Safety and caregiver satisfaction with gastrostomy in patients with Ataxia Telangiectasia. Orphanet J Rare Dis. 2011;6:23.
I agree with Dr. Goldwater that an undetected prodromal respiratory infection can suddenly fulminate and cause acute anoxic encephalopathy. In such an instance, there may not be time for visible pulmonary histological pathology to form. Then if a lung culture is not performed or gives sepsis-negative results, the cause may be coded as SIDS rather than an ARI. See Farber S. Fulminating streptococcus infections in infancy as a cause of sudden death. N Engl J Med 211:154-158, 1934 and Mage et al. .Front Neurol. 2016 Aug 23;7:129. doi: 10.3389/fneur.2016.00129. eCollection 2016. PubMed ID 27602017
I wonder if this brief report by Harvey et al. highlights where we are going wrong. Firstly, the lack of response to the QIP may just reflect the fact that we have such limited ability to influence outcomes when it comes to childhood obesity. If you are working in a busy CAU it seems pointless doing things that are not going to produce a positive outcome.
However my biggest concern is the statement: "How paediatricians act has a large impact on parents: we cannot expect them to prioritise their child’s obesity if we do not do the same." This appears to be the “nanny state” at work. The fact that parents are not recognising their children’s obesity, if this is really the case given the publicity this topic is receiving, is the main problem. This idea that patients are completely dependent on professionals to bring about change influences the outcome for many chronic conditions. Best results are obtained when patients (and carers) are actively involved in the management of the disease and are equipped to influence outcomes. This can only come about through education.
My personal experience is that I cannot remember ever seeing an overweight child maintain any significant weight loss. The lack of parental recognition of the fact that their child is overweight is a major problem. I am not sure how long the comment "your child is overweight" stays with parents after they leave the clinic. Do parents feel that an overweight child reflects well on...
I wonder if this brief report by Harvey et al. highlights where we are going wrong. Firstly, the lack of response to the QIP may just reflect the fact that we have such limited ability to influence outcomes when it comes to childhood obesity. If you are working in a busy CAU it seems pointless doing things that are not going to produce a positive outcome.
However my biggest concern is the statement: "How paediatricians act has a large impact on parents: we cannot expect them to prioritise their child’s obesity if we do not do the same." This appears to be the “nanny state” at work. The fact that parents are not recognising their children’s obesity, if this is really the case given the publicity this topic is receiving, is the main problem. This idea that patients are completely dependent on professionals to bring about change influences the outcome for many chronic conditions. Best results are obtained when patients (and carers) are actively involved in the management of the disease and are equipped to influence outcomes. This can only come about through education.
My personal experience is that I cannot remember ever seeing an overweight child maintain any significant weight loss. The lack of parental recognition of the fact that their child is overweight is a major problem. I am not sure how long the comment "your child is overweight" stays with parents after they leave the clinic. Do parents feel that an overweight child reflects well on them in that they are providing adequate amounts of food. The importance of food in our distant history must still have an influence. For the vast majority of the population, as recently as 100 years ago, food was often scarce and you ate whatever was put in front of you in case there was nothing for a while. That behaviour is now a problem, when food is freely available.
The only way this is going to change is when parents take the lead. The aim has to be to prevent children becoming overweight. Once it has happened it appears next to impossible to correct. This is a problem that only parents are in a position to manage and they must take responsibility for it, not medical professionals.
The paper by Yang et al1 provided an interesting epidemiological picture regarding the healthcare use in the year before correct diagnoses are confirmed for childhood cancer, type 1 diabetes mellitus (T1DM) and other immune diseases. Despite the presence of known clinical presentations associated with these diseases, diagnoses are not usually made until after couples of medical visits, except in cases with T1DM. Nearly two thirds of newly diagnosed T1DM patients presented emergent diabetic ketoacidosis. This rate was similar to that reported in a single-center Taiwanese study2 but still much higher than those in the US and Europe.3,4 This finding raised a question whether diabetic ketoacidosis at diagnosis of T1DM was a result of missed recognition for diabetic symptoms. In this regard, I am surprised that common urological symptoms, such as proteinuria and polydipsia2, found in Taiwanese T1DM patients were not included in the ICD-9 codes grouped for the urogenital problems, although the data showed an increase in urogenital problems shortly before the diagnosis of T1DM.1 From a clinical perspective, it is also crucial to know how the access to healthcare before diagnosis differ between those with and without diabetic ketoacidosis.3 If the analysis can be stratified by this factor, we may better evaluate the performance and impact of pre-diagnostic outpatient visits on subsequent healthcare for T1DM. There is always room for improvement in terms of increasing awareness of...
The paper by Yang et al1 provided an interesting epidemiological picture regarding the healthcare use in the year before correct diagnoses are confirmed for childhood cancer, type 1 diabetes mellitus (T1DM) and other immune diseases. Despite the presence of known clinical presentations associated with these diseases, diagnoses are not usually made until after couples of medical visits, except in cases with T1DM. Nearly two thirds of newly diagnosed T1DM patients presented emergent diabetic ketoacidosis. This rate was similar to that reported in a single-center Taiwanese study2 but still much higher than those in the US and Europe.3,4 This finding raised a question whether diabetic ketoacidosis at diagnosis of T1DM was a result of missed recognition for diabetic symptoms. In this regard, I am surprised that common urological symptoms, such as proteinuria and polydipsia2, found in Taiwanese T1DM patients were not included in the ICD-9 codes grouped for the urogenital problems, although the data showed an increase in urogenital problems shortly before the diagnosis of T1DM.1 From a clinical perspective, it is also crucial to know how the access to healthcare before diagnosis differ between those with and without diabetic ketoacidosis.3 If the analysis can be stratified by this factor, we may better evaluate the performance and impact of pre-diagnostic outpatient visits on subsequent healthcare for T1DM. There is always room for improvement in terms of increasing awareness of T1DM symptoms, ensuring early diagnosis, and preventing complications among healthcare sectors and affected families.
References
1. Yang TO, Huang W, Chen M, et al. Childhood cancer, type 1 diabetes and other immune diseases: healthcare visits in the year before diagnosis in Taiwan Archives of Disease in Childhood Published Online First: 08 February 2017. doi: 10.1136/archdischild-2016-311762
2. Chen YC, Tung YC, Liu SY, et al. Clinical characteristics of type 1 diabetes mellitus in Taiwanese children aged younger than 6 years: A single-center experience.
J Formos Med Assoc. 2016 Aug 9. doi: 10.1016/j.jfma.2016.07.005. [Epub ahead of print]
3. Baldelli L, Flitter B, Pyle L, et al. A survey of youth with new onset type 1 diabetes: Opportunities to reduce diabetic ketoacidosis. Pediatr Diabetes. 2016 Oct 11. doi: 10.1111/pedi.12455.
4. Cherubini V, Skrami E, Ferrito L, et al. High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004-2013. Sci Rep. 2016 Dec 19;6:38844. doi: 10.1038/srep38844.
Thank you for your letter and for sharing your very personal experience.
We agree with you that by the time the child who is choking is attended to by advanced medical practitioners the situation is often dire and that the best hope of a good outcome rests with prompt and effective attempts to dislodge the offending object.
However, knowing that partial airway obstruction may quickly become complete airway obstruction, that (as in the cases we describe) First Aid measures may fail, and that even if the obstruction is relieved the consequences may be significant; we would also advocate that emergency services were alerted as early as possible.
The Advanced Paediatric Life Support (APLS)1 guidance in the UK gives the clear advice with regard to first aid measures to be employed in the choking child.
• If the foreign body is easily visible then carefully try to remove it.
• If the child is coughing effectively and is conscious then encourage them to cough and monitor closely.
• If the child has an ineffective cough but is still conscious then proceed as follows:
o An infant should be laid horizontally with head down, supported with airway open (on the rescuer’s forearm or lap) and five sharp back blows delivered between the shoulder blades. If this fails then the infant is turned supine, still head down, and five chest thrusts (sharp and slower compressions using the same landmarks as for CPR) commenced.
The Heimlich m...
Thank you for your letter and for sharing your very personal experience.
We agree with you that by the time the child who is choking is attended to by advanced medical practitioners the situation is often dire and that the best hope of a good outcome rests with prompt and effective attempts to dislodge the offending object.
However, knowing that partial airway obstruction may quickly become complete airway obstruction, that (as in the cases we describe) First Aid measures may fail, and that even if the obstruction is relieved the consequences may be significant; we would also advocate that emergency services were alerted as early as possible.
The Advanced Paediatric Life Support (APLS)1 guidance in the UK gives the clear advice with regard to first aid measures to be employed in the choking child.
• If the foreign body is easily visible then carefully try to remove it.
• If the child is coughing effectively and is conscious then encourage them to cough and monitor closely.
• If the child has an ineffective cough but is still conscious then proceed as follows:
o An infant should be laid horizontally with head down, supported with airway open (on the rescuer’s forearm or lap) and five sharp back blows delivered between the shoulder blades. If this fails then the infant is turned supine, still head down, and five chest thrusts (sharp and slower compressions using the same landmarks as for CPR) commenced.
The Heimlich manoeuvre (abdominal thrusts) is not recommended in this guidance for the under 1’s since it can cause injury. However, it is well known and in extremis it would seem appropriate.
o In an older child back blows can be attempted with the child standing and leaning forward, alternated with the more traditional abdominal thrust as described by Heimlich either from behind the patient or with the patient supine and the rescuer astride.
• If the child becomes unconscious then the airway should be opened and 5 rescue breaths attempted, followed by chest compressions. Though, clearly if the airway is completely occluded the breaths will be ineffectual.
In the 3 cases we describe in the paper, we tried to outline that all episodes were witnessed by adults, promptly identified and that First Aid attempts were made to dislodge the grape at the scene by lay people and by those with training. The exact nature, timing and order of the attempts were not clear but it would appear that all appropriate manoeuvres were tried in each case.
We note that you have a question regarding the outcome of the child in our article who survived. We described this in the article but he thankfully made an excellent and complete recovery.
In conclusion, we are all too aware that by the time a child with prolonged foreign body airway obstruction reaches the Emergency Department the situation can be terminal and thank you for highlighting the importance of the dissemination of these vital First Aid skills.
Jamie Cooper and Amy Lumsden
23rd June 2017
Ref.
1. Advanced Life Support Group 2016. The choking child (section 18.4). In: Samuels M. And Wieteska S. Eds. Advanced Paediatric Life Support: a practical approach to emergencies 6th edition. Chichester UK. Wiley, pp180-185.
I'm Dr. Al-anbuqy Khalid working in HUDERF( Association Hospitalière de Bruxelles – Hôpital Universitaire des Enfants Reine Fabiola) with
professor Henri Steyaert, MD, PhD ( Avenue Jean-Joseph Crocq, 15 1020 Brussels Belgium Phone : +3224773197
Fax : +32 (0)2 477.34.49 Email : henri.steyaert@huderf.be) .We are making research over intussusception .
My question is did you used premedication or sedation in your study in all or some patients(percentage if possible), and if yes what is /are the type of premedication or sedation did you used ?
Best regards
Al-anbuqy Khalid, researcher doctor
Association Hospitalière de Bruxelles – Hôpital Universitaire des Enfants Reine Fabiola (HUDERF)
Department of paediatric Surgery
Adress :Avenue Jean-Joseph Crocq, 15,1020 Brussels,Belgium
Email : Khalid.alanbuqy@huderf.be
Phone: +32465133654
We are pleased to see the interest shown in our article by Drs Cheung and Lachman, but cannot agree with their assertion that our research ‘misses the point’.
Despite widespread use, there remains limited research on the effectiveness of paediatric early warning systems (PEWS) in detecting deterioration in hospitalised children. Our paper sought to establish if there were statistically significance differences in performance between 18 published systems. Trigger systems were out-performed by scoring-systems in this relevant but narrow assessment. Our conclusion emphasizes that it is unclear what factors account for these differences in performance.
Dr Cheung and others feel this observation of statistical inferiority of trigger system is not merited and the observed differences may be influenced by the scoring threshold selected. Dr Cheung illustrates this by comparison to the threshold selection of the C-reactive protein test as an indicator of inflammation. We found this to be rather confusing. The outcomes of trigger-based systems are, by their very nature, dichotomous. Whilst there is always a trade-off between sensitivity and specificity for scoring-based systems, the same does not apply to trigger-based systems. The system is either triggered or not. We note that Dr Cheung does not offer data to support his preference for trigger systems.
We agree that managing deterioration in children is complex. However it is hard to imagine how this would be im...
We are pleased to see the interest shown in our article by Drs Cheung and Lachman, but cannot agree with their assertion that our research ‘misses the point’.
Despite widespread use, there remains limited research on the effectiveness of paediatric early warning systems (PEWS) in detecting deterioration in hospitalised children. Our paper sought to establish if there were statistically significance differences in performance between 18 published systems. Trigger systems were out-performed by scoring-systems in this relevant but narrow assessment. Our conclusion emphasizes that it is unclear what factors account for these differences in performance.
Dr Cheung and others feel this observation of statistical inferiority of trigger system is not merited and the observed differences may be influenced by the scoring threshold selected. Dr Cheung illustrates this by comparison to the threshold selection of the C-reactive protein test as an indicator of inflammation. We found this to be rather confusing. The outcomes of trigger-based systems are, by their very nature, dichotomous. Whilst there is always a trade-off between sensitivity and specificity for scoring-based systems, the same does not apply to trigger-based systems. The system is either triggered or not. We note that Dr Cheung does not offer data to support his preference for trigger systems.
We agree that managing deterioration in children is complex. However it is hard to imagine how this would be improved through the use of a tool with reduced ability to discriminate children ‘at risk’ of deterioration, even if staff used this optimally. Or how the use of a tool with an unknown performance would improve the situation. Dr Cheung states “One would not recommend a new drug be widely used, regardless of its efficacy, without also evaluating whether the means of administration was reliable and acceptable.” We respectfully suggest that understanding whether an intervention is efficacious is a fundamental first step. There is no sense in evaluating the reliability and acceptability of ineffective interventions. The real world clinical effectiveness does indeed depend on many factors including human behaviour. However, clinicians are unlikely to adopt a system enthusiastically that does a poor job of categorising patients as high or low risk of deterioration.
Dr Cheung is correct in stating that score-based systems are inherently more complex to use, however this can be over-come by adopting ‘smart’ technology to automatically calculate scores, as we have done in our institution. As technology continues to develop it may be time for healthcare to work ‘smarter’ by embracing technological solutions to problems rather than demanding staff work ‘harder’. Neither quality nor its improvement should be constrained by the systems within which processes occur. While quality can be optimized within a system, improvement can be stunted.
Our paper sought to establish if there were differences in performance between differing systems and whether these were significant. Our findings indicate that differences do indeed exist and as such, this may be an important consideration for centres using a PEWS. As the editorial by Lillitos and Maconochie emphasises – it is time to focus on the evidence.
Berrington and Ward Platt recently summarized current advances in the management of preterm infants born < 1000 g, so called extremely low birth weight (ELBW) infants (1). In this thoroughly done review, the authors highlighted the findings of the 2014 Cochrane review showing probiotics to reduce all-cause mortality and NEC in preterm infants, but not in the subgroup of ELBW infants (2). They hypothesized the lacking protective effect in this extremely vulnerable population to be attributable to their general immaturity, the timing of probiotic exposure or the small sample size of only 575 ELBW infants analyzed. Another recent meta-analysis did not show a significant beneficial effect of probiotics on sepsis in 771 ELBW infants included (3). This demands further studies with adequate power on the use of probiotics in infants born < 1000 g. Almost at the same time, we published a multi-center time series analysis supporting the beneficial effects of dual-strain probiotics on NEC, overall-mortality and nosocomial bloodstream infections (BSI) in preterm infants (4). Beyond that, we performed a subgroup analyses with 4683 ELBW infants. Routine use of dual-strain probiotics significantly reduced the risk of NEC (HR 0.48, 95 % CI 0.36 – 0.64), overall mortality (HR 0.59, 95 % CI 0.41 – 0.84) and nosocomial BSI (HR 0.83, 95 % CI 0.74 – 0.94) in this cohort. Further, probiotics also protected ELBW infants from mortality following NEC (HR 0.40, 95 % CI 0.19 – 0.85). Up to dat...
Berrington and Ward Platt recently summarized current advances in the management of preterm infants born < 1000 g, so called extremely low birth weight (ELBW) infants (1). In this thoroughly done review, the authors highlighted the findings of the 2014 Cochrane review showing probiotics to reduce all-cause mortality and NEC in preterm infants, but not in the subgroup of ELBW infants (2). They hypothesized the lacking protective effect in this extremely vulnerable population to be attributable to their general immaturity, the timing of probiotic exposure or the small sample size of only 575 ELBW infants analyzed. Another recent meta-analysis did not show a significant beneficial effect of probiotics on sepsis in 771 ELBW infants included (3). This demands further studies with adequate power on the use of probiotics in infants born < 1000 g. Almost at the same time, we published a multi-center time series analysis supporting the beneficial effects of dual-strain probiotics on NEC, overall-mortality and nosocomial bloodstream infections (BSI) in preterm infants (4). Beyond that, we performed a subgroup analyses with 4683 ELBW infants. Routine use of dual-strain probiotics significantly reduced the risk of NEC (HR 0.48, 95 % CI 0.36 – 0.64), overall mortality (HR 0.59, 95 % CI 0.41 – 0.84) and nosocomial BSI (HR 0.83, 95 % CI 0.74 – 0.94) in this cohort. Further, probiotics also protected ELBW infants from mortality following NEC (HR 0.40, 95 % CI 0.19 – 0.85). Up to date, this is the largest study on probiotics in ELBW infants. Our findings suggest the routine use of dual-strain probiotics in standard neonatal care of infants born < 1000 g.
References
1. Berrington J, Ward Platt M. Recent advances in the management of infants born <1000 g. Archives of disease in childhood. 2016; doi: 10.1136/archdischild-2015-309583 [published Online First: 2016/05/12].
2. AlFaleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. The Cochrane database of systematic reviews. 2014;4:Cd005496 doi: 10.1002/14651858.CD005496.pub4 [published Online First: 2014/04/12].
3. Zhang GQ, Hu HJ, Liu CY, Shakya S, Li ZY. Probiotics for Preventing Late-Onset Sepsis in Preterm Neonates: A PRISMA-Compliant Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine. 2016;95:e2581 doi: 10.1097/md.0000000000002581 [published Online First: 2016/03/05].
4. Denkel LA, Schwab F, Garten L, Geffers C, Gastmeier P, Piening B. Protective Effect of Dual-Strain Probiotics in Preterm Infants: A Multi-Center Time Series Analysis. PloS one. 2016;11:e0158136 doi: 10.1371/journal.pone.0158136 [published Online First: 2016/06/23].
The need to improve outcomes in child health is not disputed, especially in the UK where performance lags behind the rest of Europe [1]. Mechanisms which detect, and respond, to the deteriorating child in an effective manner should be validated and shared so we welcome further research by Chapman et al. [2] which demonstrates the complexity of producing tools which do this. However, we support the concern raised by Cheung and Lachman [3] in ensuring that appropriate conclusions are drawn from this work. As a research group funded to investigate these systems, from both a quantitative and qualitative viewpoint, we would like to highlight some of the dangers in use of terminology in this area. The concept that systems may be a better paradigm than scores (i.e. the amalgamation of observations into binary or composite measures which determine pre-defined actions) is not new [4] and it is already recognised that both afferent and efferent limbs are vital in order to complete what Joffe described as the, “chain of events needed to improve response to inpatient deterioration.” We note Maconochie and Lillitos use the term PES (Paediatric Early Warning System) and differentiate trigger systems from PEWS (Paediatric early warning scores). It is not however clear why trigger systems are treated as separate from PEWS as the literature contains numerous examples of where a trigger type system has been labelled as a PEWS [5]. While we entirely agree there is a challenge in labelling...
The need to improve outcomes in child health is not disputed, especially in the UK where performance lags behind the rest of Europe [1]. Mechanisms which detect, and respond, to the deteriorating child in an effective manner should be validated and shared so we welcome further research by Chapman et al. [2] which demonstrates the complexity of producing tools which do this. However, we support the concern raised by Cheung and Lachman [3] in ensuring that appropriate conclusions are drawn from this work. As a research group funded to investigate these systems, from both a quantitative and qualitative viewpoint, we would like to highlight some of the dangers in use of terminology in this area. The concept that systems may be a better paradigm than scores (i.e. the amalgamation of observations into binary or composite measures which determine pre-defined actions) is not new [4] and it is already recognised that both afferent and efferent limbs are vital in order to complete what Joffe described as the, “chain of events needed to improve response to inpatient deterioration.” We note Maconochie and Lillitos use the term PES (Paediatric Early Warning System) and differentiate trigger systems from PEWS (Paediatric early warning scores). It is not however clear why trigger systems are treated as separate from PEWS as the literature contains numerous examples of where a trigger type system has been labelled as a PEWS [5]. While we entirely agree there is a challenge in labelling both scores and systems together we are not certain that the addition of a new term, PES, will aid this clarification. The PUMA study [6] is investigating the ‘multifaceted sociotechnical system’ suggested in the recent systematic review by Lambert [5] and we, in agreement with Cheung and Lachman feel that simply comparing scoring systems against each other risks missing the point that it may be the contextual ‘system’ as a whole, and not the particular form of a tool, that has the biggest impact on patient outcomes.
1. Wolfe I, Donkin A, Marmot M, et al. UK child survival in a European context: recommendations for a national Countdown Collaboration. Archives of Disease in Childhood 2015;100:907-914.
2. Chapman SM et al. ‘The Score Matters’: wide variations in predictive performance of 18 paediatric track and trigger systems. Arch Dis Child 2017; 102:487-95
3. Cheung R and Lachman P. "Human factors matter" - Statistical analysis of performance of trigger systems misses the point. In response to: Lillitos PJ, Maconochie IK. Paediatric early warning systems (PEWS and Trigger systems) for the hospitalised child: time to focus on the evidence. Arch Dis Child 2017;102: 479-80
4. Joffe AR, Anton NR, Burkholder SC. Reduction in hospital mortality over time in a hospital without a pediatric medical emergency team: limitations of before-and-after study designs. Arch Pediatr Adolesc Med 2011;165:419–23.
5. Lambert V, Matthews A, MacDonell R, et al. Paediatric early warning systems for detecting and responding to clinical deterioration in children: a systematic review BMJ Open 2017;7:e014497
6. PUMA - Paediatric early warning system (PEWS): Utilisation and Mortality Avoidance. A prospective, mixed methods, before and after study identifying the evidence base for the core components of an effective PEWS and the development of an implementation package for implementation and use in the UK HS&DR 12/178/17 https://www.journalslibrary.nihr.ac.uk/programmes/hta/1217817#/ Website last accessed 20th June 2017
In your paper [1], you did not mention a previous prospective study performed by our group [2], on 148 otherwise healthy children referred to a Sleep Center for suspected OSA. In our study, pulse oximetry metrics were similar on the two consecutive nights. The McGill Oximery Score (MOS) on the two nights showed excellent night-to-night consistency when analyzed as positive for OSA versus inconclusive. We highlighted that the findings may not apply to younger infants, to adolescents, or to children with complex comorbidities.
Our conclusions were different from yours for at least two main reasons.
Firstly, you accepted oximetry recording lasting ≥ 4 hrs. On our opinion, this cut off is too low and it cannot be sufficiently representative of an overnight study. In our study [2], we accepted recordings lasting ≥ 6 hrs according to the ATS guidelines for sleep study.
Secondly, you used a Nonin 9600 Pulse Oximeter with Nellcor neonatal-adult SpO2 sensor. In our study [2], we used a motion-resistant Radical 5 Masimo Pulse Oximeter. Previous studies [3,4], demonstrated the superiority of the Radical Masimo technology.
We believe that your study was performed using suboptimal technology and the criteria for minimum acceptable recording time didn’t respect the ATS guidelines. Therefore, your results should be considered with caution.
Convincing data already exist on pulse oximetry and the analysis of MOS as a useful tool for...
In your paper [1], you did not mention a previous prospective study performed by our group [2], on 148 otherwise healthy children referred to a Sleep Center for suspected OSA. In our study, pulse oximetry metrics were similar on the two consecutive nights. The McGill Oximery Score (MOS) on the two nights showed excellent night-to-night consistency when analyzed as positive for OSA versus inconclusive. We highlighted that the findings may not apply to younger infants, to adolescents, or to children with complex comorbidities.
Our conclusions were different from yours for at least two main reasons.
Firstly, you accepted oximetry recording lasting ≥ 4 hrs. On our opinion, this cut off is too low and it cannot be sufficiently representative of an overnight study. In our study [2], we accepted recordings lasting ≥ 6 hrs according to the ATS guidelines for sleep study.
Secondly, you used a Nonin 9600 Pulse Oximeter with Nellcor neonatal-adult SpO2 sensor. In our study [2], we used a motion-resistant Radical 5 Masimo Pulse Oximeter. Previous studies [3,4], demonstrated the superiority of the Radical Masimo technology.
We believe that your study was performed using suboptimal technology and the criteria for minimum acceptable recording time didn’t respect the ATS guidelines. Therefore, your results should be considered with caution.
Convincing data already exist on pulse oximetry and the analysis of MOS as a useful tool for detecting and grading severity of paediatric OSA, to prioritize the most severely affected children for expeditious adenotonsillectomy, to predict the likelihood of having adverse peri-operative respiratory events.
We reinforce the concept that pulse oximetry is useful when performed with appropriate motion-resistant technology, interpreted by expert physicians, and targeted to otherwise healthy children.
Children with complex pathologies deserve a different approach as suggested by ERS Guidelines and poly(somno)graphy should be performed.
References
1) Burke RM, Maxwell B, Hunter C, et al. Night-to-night variation of pulse oximetry in children with sleep disordered breathing. Arch Dis Child 2016;101:1095–9.
2) Pavone M, Cutrera R, Verrillo E, et al Night-to-night consistency of at-home nocturnal pulse oximetry testing for obstructive sleep apnea in children. Pediatr Pulmonol. 2013 Aug; 48(8):754-60.
3) Trang H, Boureghda S, Leske V. Sleep desaturation: comparison of two oximeters. Pediatr Pulmonol. 2004 Jan;37(1):76-80”.
4) Brouillette RT, Lavergne J, Leimanis A, et al. “Differences in pulse oximetry technology can affect detection of sleep-disorderd breathing in children. Anesth Analg. 2002 Jan;94(1 Suppl):S47-53”
Dear Editor,
We thank Professor Wright for her comments, and we welcome the opportunity to provide some clarification and further analysis.
We reported Z-scores rather than percentiles, although some comments on approximate percentiles can be made. Assuming that Z scores of -1.96 and -3 represent approximately the 2.5th and 0.2nd centiles respectively, 36/101 children were below the 2.5th centile, and 17/101 were below the 0.2nd centile for weight. Additionally, our mixed effects model (accounting for multiple measurements) modelling the group trend over time estimated the mean weight Z score at 11 years to be -1.63 (approximately 5th centile).
Despite the overall short stature of the group, 24/101 children had a BMI Z score of less than -1.96. So, by this approach, their weight was low even after taking into account stature. We agree that we cannot infer causality from this observational study, but we believe a proportion of the stunted growth is explained by low weight. We are exploring other measures of malnutrition, such as skin-fold thickness.
Whilst our patient numbers are small, they do give some weight to the argument that PEG feeding halts the progression of malnutrition. We investigated the rate of decline of weight after PEG insertion. In a mixed effects model with a random intercept for individual patients, the rate of wei...
Show MoreI agree with Dr. Goldwater that an undetected prodromal respiratory infection can suddenly fulminate and cause acute anoxic encephalopathy. In such an instance, there may not be time for visible pulmonary histological pathology to form. Then if a lung culture is not performed or gives sepsis-negative results, the cause may be coded as SIDS rather than an ARI. See Farber S. Fulminating streptococcus infections in infancy as a cause of sudden death. N Engl J Med 211:154-158, 1934 and Mage et al. .Front Neurol. 2016 Aug 23;7:129. doi: 10.3389/fneur.2016.00129. eCollection 2016. PubMed ID 27602017
I wonder if this brief report by Harvey et al. highlights where we are going wrong. Firstly, the lack of response to the QIP may just reflect the fact that we have such limited ability to influence outcomes when it comes to childhood obesity. If you are working in a busy CAU it seems pointless doing things that are not going to produce a positive outcome.
Show MoreHowever my biggest concern is the statement: "How paediatricians act has a large impact on parents: we cannot expect them to prioritise their child’s obesity if we do not do the same." This appears to be the “nanny state” at work. The fact that parents are not recognising their children’s obesity, if this is really the case given the publicity this topic is receiving, is the main problem. This idea that patients are completely dependent on professionals to bring about change influences the outcome for many chronic conditions. Best results are obtained when patients (and carers) are actively involved in the management of the disease and are equipped to influence outcomes. This can only come about through education.
My personal experience is that I cannot remember ever seeing an overweight child maintain any significant weight loss. The lack of parental recognition of the fact that their child is overweight is a major problem. I am not sure how long the comment "your child is overweight" stays with parents after they leave the clinic. Do parents feel that an overweight child reflects well on...
The paper by Yang et al1 provided an interesting epidemiological picture regarding the healthcare use in the year before correct diagnoses are confirmed for childhood cancer, type 1 diabetes mellitus (T1DM) and other immune diseases. Despite the presence of known clinical presentations associated with these diseases, diagnoses are not usually made until after couples of medical visits, except in cases with T1DM. Nearly two thirds of newly diagnosed T1DM patients presented emergent diabetic ketoacidosis. This rate was similar to that reported in a single-center Taiwanese study2 but still much higher than those in the US and Europe.3,4 This finding raised a question whether diabetic ketoacidosis at diagnosis of T1DM was a result of missed recognition for diabetic symptoms. In this regard, I am surprised that common urological symptoms, such as proteinuria and polydipsia2, found in Taiwanese T1DM patients were not included in the ICD-9 codes grouped for the urogenital problems, although the data showed an increase in urogenital problems shortly before the diagnosis of T1DM.1 From a clinical perspective, it is also crucial to know how the access to healthcare before diagnosis differ between those with and without diabetic ketoacidosis.3 If the analysis can be stratified by this factor, we may better evaluate the performance and impact of pre-diagnostic outpatient visits on subsequent healthcare for T1DM. There is always room for improvement in terms of increasing awareness of...
Show MoreThank you for your letter and for sharing your very personal experience.
Show MoreWe agree with you that by the time the child who is choking is attended to by advanced medical practitioners the situation is often dire and that the best hope of a good outcome rests with prompt and effective attempts to dislodge the offending object.
However, knowing that partial airway obstruction may quickly become complete airway obstruction, that (as in the cases we describe) First Aid measures may fail, and that even if the obstruction is relieved the consequences may be significant; we would also advocate that emergency services were alerted as early as possible.
The Advanced Paediatric Life Support (APLS)1 guidance in the UK gives the clear advice with regard to first aid measures to be employed in the choking child.
• If the foreign body is easily visible then carefully try to remove it.
• If the child is coughing effectively and is conscious then encourage them to cough and monitor closely.
• If the child has an ineffective cough but is still conscious then proceed as follows:
o An infant should be laid horizontally with head down, supported with airway open (on the rescuer’s forearm or lap) and five sharp back blows delivered between the shoulder blades. If this fails then the infant is turned supine, still head down, and five chest thrusts (sharp and slower compressions using the same landmarks as for CPR) commenced.
The Heimlich m...
Dear Sir
I'm Dr. Al-anbuqy Khalid working in HUDERF( Association Hospitalière de Bruxelles – Hôpital Universitaire des Enfants Reine Fabiola) with
professor Henri Steyaert, MD, PhD ( Avenue Jean-Joseph Crocq, 15 1020 Brussels Belgium Phone : +3224773197
Fax : +32 (0)2 477.34.49 Email : henri.steyaert@huderf.be) .We are making research over intussusception .
My question is did you used premedication or sedation in your study in all or some patients(percentage if possible), and if yes what is /are the type of premedication or sedation did you used ?
Best regards
Al-anbuqy Khalid, researcher doctor
Association Hospitalière de Bruxelles – Hôpital Universitaire des Enfants Reine Fabiola (HUDERF)
Department of paediatric Surgery
Adress :Avenue Jean-Joseph Crocq, 15,1020 Brussels,Belgium
Email : Khalid.alanbuqy@huderf.be
Phone: +32465133654
We are pleased to see the interest shown in our article by Drs Cheung and Lachman, but cannot agree with their assertion that our research ‘misses the point’.
Show MoreDespite widespread use, there remains limited research on the effectiveness of paediatric early warning systems (PEWS) in detecting deterioration in hospitalised children. Our paper sought to establish if there were statistically significance differences in performance between 18 published systems. Trigger systems were out-performed by scoring-systems in this relevant but narrow assessment. Our conclusion emphasizes that it is unclear what factors account for these differences in performance.
Dr Cheung and others feel this observation of statistical inferiority of trigger system is not merited and the observed differences may be influenced by the scoring threshold selected. Dr Cheung illustrates this by comparison to the threshold selection of the C-reactive protein test as an indicator of inflammation. We found this to be rather confusing. The outcomes of trigger-based systems are, by their very nature, dichotomous. Whilst there is always a trade-off between sensitivity and specificity for scoring-based systems, the same does not apply to trigger-based systems. The system is either triggered or not. We note that Dr Cheung does not offer data to support his preference for trigger systems.
We agree that managing deterioration in children is complex. However it is hard to imagine how this would be im...
Berrington and Ward Platt recently summarized current advances in the management of preterm infants born < 1000 g, so called extremely low birth weight (ELBW) infants (1). In this thoroughly done review, the authors highlighted the findings of the 2014 Cochrane review showing probiotics to reduce all-cause mortality and NEC in preterm infants, but not in the subgroup of ELBW infants (2). They hypothesized the lacking protective effect in this extremely vulnerable population to be attributable to their general immaturity, the timing of probiotic exposure or the small sample size of only 575 ELBW infants analyzed. Another recent meta-analysis did not show a significant beneficial effect of probiotics on sepsis in 771 ELBW infants included (3). This demands further studies with adequate power on the use of probiotics in infants born < 1000 g. Almost at the same time, we published a multi-center time series analysis supporting the beneficial effects of dual-strain probiotics on NEC, overall-mortality and nosocomial bloodstream infections (BSI) in preterm infants (4). Beyond that, we performed a subgroup analyses with 4683 ELBW infants. Routine use of dual-strain probiotics significantly reduced the risk of NEC (HR 0.48, 95 % CI 0.36 – 0.64), overall mortality (HR 0.59, 95 % CI 0.41 – 0.84) and nosocomial BSI (HR 0.83, 95 % CI 0.74 – 0.94) in this cohort. Further, probiotics also protected ELBW infants from mortality following NEC (HR 0.40, 95 % CI 0.19 – 0.85). Up to dat...
Show MoreThe need to improve outcomes in child health is not disputed, especially in the UK where performance lags behind the rest of Europe [1]. Mechanisms which detect, and respond, to the deteriorating child in an effective manner should be validated and shared so we welcome further research by Chapman et al. [2] which demonstrates the complexity of producing tools which do this. However, we support the concern raised by Cheung and Lachman [3] in ensuring that appropriate conclusions are drawn from this work. As a research group funded to investigate these systems, from both a quantitative and qualitative viewpoint, we would like to highlight some of the dangers in use of terminology in this area. The concept that systems may be a better paradigm than scores (i.e. the amalgamation of observations into binary or composite measures which determine pre-defined actions) is not new [4] and it is already recognised that both afferent and efferent limbs are vital in order to complete what Joffe described as the, “chain of events needed to improve response to inpatient deterioration.” We note Maconochie and Lillitos use the term PES (Paediatric Early Warning System) and differentiate trigger systems from PEWS (Paediatric early warning scores). It is not however clear why trigger systems are treated as separate from PEWS as the literature contains numerous examples of where a trigger type system has been labelled as a PEWS [5]. While we entirely agree there is a challenge in labelling...
Show MoreDear Authors.
In your paper [1], you did not mention a previous prospective study performed by our group [2], on 148 otherwise healthy children referred to a Sleep Center for suspected OSA. In our study, pulse oximetry metrics were similar on the two consecutive nights. The McGill Oximery Score (MOS) on the two nights showed excellent night-to-night consistency when analyzed as positive for OSA versus inconclusive. We highlighted that the findings may not apply to younger infants, to adolescents, or to children with complex comorbidities.
Our conclusions were different from yours for at least two main reasons.
Firstly, you accepted oximetry recording lasting ≥ 4 hrs. On our opinion, this cut off is too low and it cannot be sufficiently representative of an overnight study. In our study [2], we accepted recordings lasting ≥ 6 hrs according to the ATS guidelines for sleep study.
Secondly, you used a Nonin 9600 Pulse Oximeter with Nellcor neonatal-adult SpO2 sensor. In our study [2], we used a motion-resistant Radical 5 Masimo Pulse Oximeter. Previous studies [3,4], demonstrated the superiority of the Radical Masimo technology.
We believe that your study was performed using suboptimal technology and the criteria for minimum acceptable recording time didn’t respect the ATS guidelines. Therefore, your results should be considered with caution.
Convincing data already exist on pulse oximetry and the analysis of MOS as a useful tool for...
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