[PDF][PDF] The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission
Although eukaryotic protein kinases (ePKs) contribute to many cellular processes, only three
Plasmodium falciparum ePKs have thus far been identified as essential for parasite asexual …
Plasmodium falciparum ePKs have thus far been identified as essential for parasite asexual …
Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs
MJ Delves, A Ruecker, U Straschil… - Antimicrobial agents …, 2013 - Am Soc Microbiol
It is the mature gametocytes of Plasmodium that are solely responsible for parasite
transmission from the mammalian host to the mosquito. They are therefore a logical target …
transmission from the mammalian host to the mosquito. They are therefore a logical target …
Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions
MJ Delves, U Straschil, A Ruecker, C Miguel-Blanco… - Nature protocols, 2016 - nature.com
The prevention of parasite transmission from the human host to the mosquito has been
recognized as a vital tool for malaria eradication campaigns. However, transmission …
recognized as a vital tool for malaria eradication campaigns. However, transmission …
[HTML][HTML] Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation
Reversible protein phosphorylation regulated by kinases and phosphatases controls many
cellular processes. Although essential functions for the malaria parasite kinome have been …
cellular processes. Although essential functions for the malaria parasite kinome have been …
[HTML][HTML] A high throughput screen for next-generation leads targeting malaria parasite transmission
MJ Delves, C Miguel-Blanco, H Matthews… - Nature …, 2018 - nature.com
Spread of parasite resistance to artemisinin threatens current frontline antimalarial
therapies, highlighting the need for new drugs with alternative modes of action. Since only …
therapies, highlighting the need for new drugs with alternative modes of action. Since only …
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
B Baragaña, B Forte, R Choi… - Proceedings of the …, 2019 - National Acad Sciences
Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of
global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in …
global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in …
Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality
K Slavic, U Straschil, L Reininger… - Molecular …, 2010 - Wiley Online Library
A Plasmodium falciparum hexose transporter (PfHT) has previously been shown to be a
facilitative glucose and fructose transporter. Its expression in Xenopus laevis oocytes and …
facilitative glucose and fructose transporter. Its expression in Xenopus laevis oocytes and …
[HTML][HTML] A Unique Protein Phosphatase with Kelch-Like Domains (PPKL) in Plasmodium Modulates Ookinete Differentiation, Motility and Invasion
DS Guttery, B Poulin, DJP Ferguson, B Szöőr… - 2012 - journals.plos.org
Protein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases,
respectively) are post-translational modifications that play key roles in many eukaryotic …
respectively) are post-translational modifications that play key roles in many eukaryotic …
[PDF][PDF] Plasmodium merozoite TRAP family protein is essential for vacuole membrane disruption and gamete egress from erythrocytes
DY Bargieri, S Thiberge, CL Tay, AF Carey, A Rantz… - Cell host & …, 2016 - cell.com
Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are
conserved across the phylum of apicomplexan parasites. TRAP proteins are thought to play …
conserved across the phylum of apicomplexan parasites. TRAP proteins are thought to play …
[HTML][HTML] The Armadillo Repeat Protein PF16 Is Essential for Flagellar Structure and Function in Plasmodium Male Gametes
U Straschil, AM Talman, DJP Ferguson, KA Bunting… - PloS one, 2010 - journals.plos.org
Malaria, caused by the apicomplexan parasite Plasmodium, threatens 40% of the world's
population. Transmission between vertebrate and insect hosts depends on the sexual …
population. Transmission between vertebrate and insect hosts depends on the sexual …