[PDF][PDF] The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission

R Tewari, U Straschil, A Bateman, U Böhme… - Cell host & …, 2010 - cell.com
Although eukaryotic protein kinases (ePKs) contribute to many cellular processes, only three
Plasmodium falciparum ePKs have thus far been identified as essential for parasite asexual …

Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs

MJ Delves, A Ruecker, U Straschil… - Antimicrobial agents …, 2013 - Am Soc Microbiol
It is the mature gametocytes of Plasmodium that are solely responsible for parasite
transmission from the mammalian host to the mosquito. They are therefore a logical target …

Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions

MJ Delves, U Straschil, A Ruecker, C Miguel-Blanco… - Nature protocols, 2016 - nature.com
The prevention of parasite transmission from the human host to the mosquito has been
recognized as a vital tool for malaria eradication campaigns. However, transmission …

[HTML][HTML] Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation

DS Guttery, B Poulin, A Ramaprasad, RJ Wall… - Cell host & …, 2014 - cell.com
Reversible protein phosphorylation regulated by kinases and phosphatases controls many
cellular processes. Although essential functions for the malaria parasite kinome have been …

[HTML][HTML] A high throughput screen for next-generation leads targeting malaria parasite transmission

MJ Delves, C Miguel-Blanco, H Matthews… - Nature …, 2018 - nature.com
Spread of parasite resistance to artemisinin threatens current frontline antimalarial
therapies, highlighting the need for new drugs with alternative modes of action. Since only …

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

B Baragaña, B Forte, R Choi… - Proceedings of the …, 2019 - National Acad Sciences
Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of
global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in …

Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality

K Slavic, U Straschil, L Reininger… - Molecular …, 2010 - Wiley Online Library
A Plasmodium falciparum hexose transporter (PfHT) has previously been shown to be a
facilitative glucose and fructose transporter. Its expression in Xenopus laevis oocytes and …

[HTML][HTML] A Unique Protein Phosphatase with Kelch-Like Domains (PPKL) in Plasmodium Modulates Ookinete Differentiation, Motility and Invasion

DS Guttery, B Poulin, DJP Ferguson, B Szöőr… - 2012 - journals.plos.org
Protein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases,
respectively) are post-translational modifications that play key roles in many eukaryotic …

[PDF][PDF] Plasmodium merozoite TRAP family protein is essential for vacuole membrane disruption and gamete egress from erythrocytes

DY Bargieri, S Thiberge, CL Tay, AF Carey, A Rantz… - Cell host & …, 2016 - cell.com
Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are
conserved across the phylum of apicomplexan parasites. TRAP proteins are thought to play …

[HTML][HTML] The Armadillo Repeat Protein PF16 Is Essential for Flagellar Structure and Function in Plasmodium Male Gametes

U Straschil, AM Talman, DJP Ferguson, KA Bunting… - PloS one, 2010 - journals.plos.org
Malaria, caused by the apicomplexan parasite Plasmodium, threatens 40% of the world's
population. Transmission between vertebrate and insect hosts depends on the sexual …