Ropivacaine (Naropin®, AstraZeneca) a new long-acting amide local anaesthetic agent, is a
pure S-enantiomer, with a high pKa and relatively low-lipid solubility. Since its clinical …

This initiative addresses the well known perioperative risks in young children, perioperative
causes for cerebral morbidity as well as gaps in regulations, teaching and research …

A multitude of animal studies have shown that virtually all general anesthetics used in
clinical practice possibly during a vulnerable period of brain development (ie, brain growth …

Background Little is known about the incidence of severe critical events in children
undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and …

Background Although animal studies have indicated that general anesthetics may result in
widespread apoptotic neurodegeneration and neurocognitive impairment in the developing …

Background The aim of this study was to describe acetaminophen developmental
pharmacokinetics in premature neonates through infancy to suggest age-appropriate dosing …

Background Neonates and infants requiring anaesthesia are at risk of physiological
instability and complications, but triggers for peri-anaesthetic interventions and associations …

Background: Paracetamol (N‐acetyl‐p‐amino‐phenol) or acetaminophen has become the
most widely used analgesic and antipyretic in children. However, there is a wide …

Background Postoperative cognitive dysfunction is common, but it remains unclear whether
there are long-term adverse cognitive effects of surgery combined with anesthesia. The …

Background Immature animals exposed to anesthetics display apoptotic neurodegeneration
with subsequent long‐term cognitive dysfunctions. Young age at anesthetic exposure is …