Astrocytic tumors account for 42% of childhood brain tumors, arising in all anatomical
regions and associated with neurofibromatosis type 1 (NF1) in 15%. Anatomical site …

Purpose It is often assumed that prolonged time to diagnosis (TTD) for cancer negatively
influences overall survival and survivorship through advanced stage disease at diagnosis …

Objectives Cisplatin ototoxicity affects 42–88% of treated children. Catechol-O-
methyltransferase (COMT), thiopurine methyltransferase (TPMT) and AYCP2 genetic …

Purpose EURAMOS-1, an international randomized controlled trial, investigated
maintenance therapy with pegylated interferon alfa-2b (IFN-α-2b) in patients whose …

The purpose of this study was to identify risk factors for the progression of low-grade glioma
in children from a large population-based cohort. Patient and tumor details of a national …

We investigated a family with an autosomal recessive syndrome of café-au-lait patches and
childhood malignancy, notably supratentorial primitive neuroectodermal tumor. There was …

ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 in
3 infants with multisystemic disease involving the liver and hematopoietic system. This entity …

Background The use of chemotherapy to manage newly diagnosed low grade glioma (LGG)
was first introduced in the 1980s. One randomised trial has studied two-versus four-drug …

Through exome sequencing, we identified six individuals with biallelic loss-of-function
mutations in TRIP13. All six developed Wilms tumor. Constitutional mosaic aneuploidies …

BACKGROUND: The treatment of previously irradiated patients with recurrent central
nervous system primitive neuroectodermal tumours (PNETs) is a considerable challenge. A …