A role for somatic mutations in carcinogenesis is well accepted, but the degree to which
mutation rates influence cancer initiation and development is under continuous debate …

Major international projects are underway that are aimed at creating a comprehensive
catalogue of all the genes responsible for the initiation and progression of cancer …

Recent studies indicate that a subclass of APOBEC cytidine deaminases, which convert
cytosine to uracil during RNA editing and retrovirus or retrotransposon restriction, may …

The initiation, progression, and relapse of cancers often result from mutations occurring
within somatic cells. Consequently, processes that elevate mutation rates accelerate …

UV radiation induces photolesions that distort the DNA double helix and, if not repaired, can
cause severe biological consequences, including mutagenesis or cell death. In eukaryotes …

Mutations are typically perceived as random, independent events. We describe here
nonrandom clustered mutations in yeast and in human cancers. Genome sequencing of …

Elucidation of mutagenic processes shaping cancer genomes is a fundamental problem
whose solution promises insights into new treatment, diagnostic and prevention strategies …

DNA polymerase theta (Pol θ)-mediated end joining (TMEJ) has been implicated in the
repair of chromosome breaks, but its cellular mechanism and role relative to canonical …

Mammalian cells require non-homologous end joining (NHEJ) for the efficient repair of
chromosomal DNA double-strand breaks. A key feature of biological sources of strand …

APOBEC family cytidine deaminases have recently been implicated as powerful mutators of
cancer genomes. How APOBECs, which are ssDNA-specific enzymes, gain access to …