Survivin, an inhibitor of apoptosis protein, is highly expressed in most cancers and
associated with chemotherapy resistance, increased tumor recurrence, and shorter patient …

Chemokines direct the movement of leukocytes, including hematopoietic stem and
progenitor cells, and can mobilize hematopoietic cells from marrow to peripheral blood …

The inhibitor-of-apoptosis protein survivin is expressed in most cancers and leukemias and
during fetal development, but not in most normal adult tissues. Survivin expression was …

The receptor tyrosine kinase Flt3 plays an important role in proliferation and survival of
hematopoietic stem and progenitor cells. Although some post-receptor signaling events of …

Mobilized peripheral blood stem cells (PBSCs) are widely used for transplantation, but
mechanisms mediating their release from marrow are poorly understood. We previously …

We cloned and sequenced a full-length cDNA of human placental N-acetylgalactosamine-6-
sulfate sulfatase, the enzyme deficient in Morquio disease. The 2339-nucleotide sequence …

Background Expanded newborn screening (ENBS) utilizing tandem mass spectrometry
(MS/MS) for inborn metabolic diseases (IMDs), such as organic acidemias (OAs), fatty acid …

Karyotypic abnormalities in cultured embryonic stem cells (ESCs), especially near-diploid
aneuploidy, are potential obstacles to ESC use in regenerative medicine. Events causing …

Hematopoietic stem cell transplantation is a potential curative therapy for malignant and
nonmalignant diseases. Improving the efficiency of stem cell collection and the quality of the …

Flt3 ligand (FL) enhances hematopoietic cell proliferation and facilitates hematopoietic stem
cell mobilization in vivo, while the stromal-derived factor 1α (SDF-1α, CXC ligand 12 …