The maturation of organ systems during fetal life and childhood exerts a profound effect on
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …

During human development impressive changes in drug disposition occur. An important
determinant of drug clearance is metabolism, something that is not only determined by …

The critical importance of membrane‐bound transporters in pharmacotherapy is widely
recognized, but little is known about drug transporter activity in children. In this white paper …

Importance Continuous morphine infusion as standard postoperative analgesic therapy in
young infants is associated with unwanted adverse effects such as respiratory depression …

Patient groups prone to polypharmacy and special subpopulations are susceptible to
suboptimal treatment. Refined dosing in special populations is imperative to improve …

Purpose Sedatives administered to critically ill children should be titrated to effect, because
both under-and oversedation may have negative effects. We conducted a systematic review …

The release and absorption profile of an oral medication is influenced by the
physicochemical properties of the drug and its formulation, as well as by the anatomy and …

Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Many drugs prescribed to children are drug transporter substrates. Drug transporters are
membrane-bound proteins that mediate the cellular uptake or efflux of drugs and are …

Introduction: Reiki is an ancient form of Japanese healing. While this healing method is
widely used for a variety of psychologic and physical symptoms, evidence of its effectiveness …