User profiles for "author:S R Bloom"
Stephen R. BloomImperial College London Verified email at imperial.ac.uk Cited by 153765 |
[HTML][HTML] Glucagon-like peptide 1 (GLP-1)
TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
Gut hormones and the regulation of energy homeostasis
KG Murphy, SR Bloom - Nature, 2006 - nature.com
Food intake, energy expenditure and body adiposity are homeostatically regulated. Central
and peripheral signals communicate information about the current state of energy balance to …
and peripheral signals communicate information about the current state of energy balance to …
The role of gut hormones and the hypothalamus in appetite regulation
K Suzuki, KA Simpson, JS Minnion, JC Shillito… - Endocrine …, 2010 - jstage.jst.go.jp
The World Health Organisation has estimated that by 2015 approximately 2.3 billion adults
will be overweight and more than 700 million obese. Obesity is associated with an increased …
will be overweight and more than 700 million obese. Obesity is associated with an increased …
Gut hormone PYY3-36 physiologically inhibits food intake
Food intake is regulated by the hypothalamus, including the melanocortin and neuropeptide
Y (NPY) systems in the arcuate nucleus. The NPY Y2 receptor (Y2R), a putative inhibitory …
Y (NPY) systems in the arcuate nucleus. The NPY Y2 receptor (Y2R), a putative inhibitory …
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
Nutritional deprivation suppresses immune function,,. The cloning of the obese gene and
identification of its protein product leptin has provided fundamental insight into the …
identification of its protein product leptin has provided fundamental insight into the …
[HTML][HTML] Inhibition of Food Intake in Obese Subjects by Peptide YY3–36
RL Batterham, MA Cohen, SM Ellis… - … England Journal of …, 2003 - Mass Medical Soc
Background The gut hormone fragment peptide YY3–36 (PYY) reduces appetite and food
intake when infused into subjects of normal weight. In common with the adipocyte hormone …
intake when infused into subjects of normal weight. In common with the adipocyte hormone …
Ghrelin causes hyperphagia and obesity in rats
AM Wren, CJ Small, CR Abbott, WS Dhillo, LJ Seal… - Diabetes, 2001 - Am Diabetes Assoc
Ghrelin, a circulating growth hormone–releasing peptide derived from the stomach,
stimulates food intake. The lowest systemically effective orexigenic dose of ghrelin was …
stimulates food intake. The lowest systemically effective orexigenic dose of ghrelin was …
The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion
AM Wren, CJ Small, HL Ward, KG Murphy… - …, 2000 - academic.oup.com
Ghrelin, a novel 28 amino acid peptide found in hypothalamus and stomach, was recently
identified as the endogenous ligand for the growth hormone secretagogue receptor (GHS …
identified as the endogenous ligand for the growth hormone secretagogue receptor (GHS …
Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
Objective: To study the effect of bariatric surgery on the entero-hypothalamic endocrine axis
of humans and rodents. Background: Bariatric surgery is the most effective obesity treatment …
of humans and rodents. Background: Bariatric surgery is the most effective obesity treatment …
Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
ES Chambers, A Viardot, A Psichas, DJ Morrison… - Gut, 2015 - gut.bmj.com
Objective The colonic microbiota ferment dietary fibres, producing short chain fatty acids.
Recent evidence suggests that the short chain fatty acid propionate may play an important …
Recent evidence suggests that the short chain fatty acid propionate may play an important …