Pediatric pulmonary hypertension
Pulmonary hypertension (PH) is a rare disease in newborns, infants, and children that is
associated with significant morbidity and mortality. In the majority of pediatric patients, PH is …
associated with significant morbidity and mortality. In the majority of pediatric patients, PH is …
Development and pathology of pulmonary hypertension
The Development and Pathology working group was charged with reviewing the present
knowledge, gaps in understanding, and areas for further studies in a broad range of themes …
knowledge, gaps in understanding, and areas for further studies in a broad range of themes …
End points and clinical trial designs in pulmonary arterial hypertension: clinical and regulatory perspectives
MM Hoeper, RJ Oudiz, A Peacock, VF Tapson… - Journal of the American …, 2004 - jacc.org
To date, randomized controlled clinical trials performed in pulmonary arterial hypertension
(PAH) have been relatively short-term studies involving mainly patients with advanced …
(PAH) have been relatively short-term studies involving mainly patients with advanced …
Lung biopsy in congenital heart disease: a morphometric approach to pulmonary vascular disease.
M Rabinovitch, SG Haworth, AR Castaneda… - Circulation, 1978 - Am Heart Assoc
Fifty patients with congenital heart disease, ages 2 days-30 years (median 12 months) at
cardiac surgery, underwent lung biopsy to assess pulmonary vascular disease (PVD) …
cardiac surgery, underwent lung biopsy to assess pulmonary vascular disease (PVD) …
The 6-minute walk test: normal values for children of 4–11 years of age
AE Lammers, AA Hislop, Y Flynn… - Archives of disease in …, 2008 - adc.bmj.com
Objective: The 6-minute walk test (6MWT) is an established measure of exercise capacity in
adults and children with chronic cardiac or respiratory disease. Despite its widespread use …
adults and children with chronic cardiac or respiratory disease. Despite its widespread use …
A consensus approach to the classification of pediatric pulmonary hypertensive vascular disease: Report from the PVRI Pediatric Taskforce, Panama 2011
MJ Del Cerro, S Abman, G Diaz… - Pulmonary …, 2011 - journals.sagepub.com
Current classifications of pulmonary hypertension have contributed a great deal to our
understanding of pulmonary vascular disease, facilitated drug trials, and improved our …
understanding of pulmonary vascular disease, facilitated drug trials, and improved our …
Treatment and survival in children with pulmonary arterial hypertension: the UK Pulmonary Hypertension Service for Children 2001–2006
SG Haworth, AA Hislop - Heart, 2009 - heart.bmj.com
Objective: A retrospective study of the UK Pulmonary Hypertension Service for Children for
the first 5-year period of its existence. Design and patients: Records of 216 children with …
the first 5-year period of its existence. Design and patients: Records of 216 children with …
Transforming growth factor-β receptor mutations and pulmonary arterial hypertension in childhood
RE Harrison, R Berger, SG Haworth, R Tulloh… - Circulation, 2005 - Am Heart Assoc
Background—Pulmonary arterial hypertension (PAH) is a potentially fatal vasculopathy that
can develop at any age. Adult-onset disease has previously been associated with mutations …
can develop at any age. Adult-onset disease has previously been associated with mutations …
Childhood idiopathic pulmonary arterial hypertension: a national cohort study
S Moledina, AA Hislop, H Foster, I Schulze-Neick… - Heart, 2010 - heart.bmj.com
Objective To clarify the clinical characteristics and epidemiology of idiopathic pulmonary
arterial hypertension (IPAH) in childhood, a rare condition with a bad prognosis, poorly …
arterial hypertension (IPAH) in childhood, a rare condition with a bad prognosis, poorly …
Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension
E Falcetti, SM Hall, PG Phillips, J Patel… - American journal of …, 2010 - atsjournals.org
Rationale: Prostacyclin analogs, used to treat idiopathic pulmonary arterial hypertension
(IPAH), are assumed to work through prostacyclin (IP) receptors linked to cyclic AMP (cAMP) …
(IPAH), are assumed to work through prostacyclin (IP) receptors linked to cyclic AMP (cAMP) …