Virtual screening with AutoDock: theory and practice

S Cosconati, S Forli, AL Perryman… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: Virtual screening is a computer-based technique for identifying
promising compounds to bind to a target molecule of known structure. Given the rapidly …

Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

M Tassabehji, AP Read, VE Newton, R Harris… - Nature, 1992 - nature.com
Abstract WAARDENGURG'S syndrome (WS) is an autosomal dominant combination of
deafness and pigmentary disturbances, probably caused by defective function of the …

Outcome of pregnancy in women with Marfan's syndrome

KJ Lipscomb, J Clayton Smith, B Clarke… - … Journal of Obstetrics …, 1997 - Wiley Online Library
Objective To improve life expectancy and prevent premature mortality in women with
Marfan's syndrome. Methods During the development of a regional genetic register for …

Automated prediction of ligand‐binding sites in proteins

R Harris, AJ Olson, DS Goodsell - Proteins: structure, function …, 2008 - Wiley Online Library
We present a method, termed AutoLigand, for the prediction of ligand‐binding sites in
proteins of known structure. The method searches the space surrounding the protein and …

Selective adsorption of dyes and other organic molecules to kaolinite and oxide surfaces

RG Harris, JD Wells, BB Johnson - Colloids and Surfaces A …, 2001 - Elsevier
Adsorption of 23 organic molecules, including a number of polyaromatic dyes, from aqueous
solution to kaolinite and amorphous alumina was measured at pH 9. For 22 of the 23 …

The onset of convective instability in a triply diffusive fluid layer

AJ Pearlstein, RM Harris, G Terrones - Journal of Fluid Mechanics, 1989 - cambridge.org
The onset of instability is investigated in a triply diffusive fluid layer in which the density
depends on three stratifying agencies having different diffusivities. It is found that, in some …

Severe Gardner syndrome in families with mutations restricted to a specific region of the APC gene

DR Davies, JG Armstrong, N Thakker… - American journal of …, 1995 - ncbi.nlm.nih.gov
Familial adenomatous polyposis (FAP) is associated with a number of extraintestinal
manifestations, which include osteomas, epidermoid cysts, and desmoid tumors, often …

Mutations in the PAX3 gene causing Waardenburg syndrome type 1 and type 2

M Tassabehji, AP Read, VE Newton, M Patton… - Nature …, 1993 - nature.com
Waardenburg syndrome (WS) is a combination of deafness and pigmentary disturbances,
normally inherited as an autosomal dominant trait. The pathology involves neural crest …

Uptake of presymptomatic predictive testing for Huntington's disease

D Craufurd, L Kerzin-Storrar, A Dodge, R Harris - The Lancet, 1989 - Elsevier
Predictive testing by means of gene probes was offered to 110 adults at risk of Huntington's
disease (HD). A further 91 individuals spontaneously sought predictive testing. Acceptance …

Intranasal vaccination with ISCOMATRIX® adjuvanted influenza vaccine

A Coulter, R Harris, R Davis, D Drane, J Cox, D Ryan… - Vaccine, 2003 - Elsevier
Mucosal delivery of inactivated vaccines that are able to elicit protective immune responses
against respiratory diseases has been a long time goal of vaccinologists. Such vaccines …