Purpose: With the increasing use of ifosfamide in pe-diatric malignancies, nephrotoxicity has
emerged as a potentially serious adverse effect, which may be doselimiting or may cause …

Although there are high survival rates for children with acute lymphoblastic leukaemia, their
outcome is often counterbalanced by the burden of toxic effects. This is because reported …

Purpose Female survivors of childhood, adolescent, and young adult (CAYA) cancer who
were treated with alkylating agents and/or radiation, with potential exposure of the ovaries …

Context Survivors of childhood cancer are at increased risk of premature mortality compared
with the general population, but little is known about the long-term risks of specific causes of …

Childhood and young adult cancer survivors should receive optimum care to reduce the
consequences of late effects and improve quality of life. We can facilitate achieving this goal …

Treatment with chemotherapy, radiotherapy, or surgery that involves reproductive organs
can cause impaired spermatogenesis, testosterone deficiency, and physical sexual …

Female survivors of childhood, adolescent, and young adult (CAYA) cancer who were given
radiation to fields that include breast tissue (ie, chest radiation) have an increased risk of …

Many childhood cancer survivors carry a significant risk for late morbidity and mortality, a
consequence of the numerous therapeutic exposures that contribute to their cure. Focused …

Substantial improvements in survival after treatment for malignant disease in childhood are
leading to a rapidly increasing number of long-term survivors, many of whom are now adults …

Male patients with childhood, adolescent, and young adult cancer are at an increased risk
for infertility if their treatment adversely affects reproductive organ function. Future fertility is a …