Ionic selectivity revisited: the role of kinetic and equilibrium processes in ion permeation through channels

G Eisenman, R Horn - The Journal of membrane biology, 1983 - Springer
The intent of this paper is to bring up to date an earlier theory of equilibrium selectivity [23,
24], with emphasis on making it applicable to the permeation of membrane channels and …

Muscarinic activation of ionic currents measured by a new whole-cell recording method.

R Horn, A Marty - The Journal of general physiology, 1988 - rupress.org
A new method is described as an alternative to whole-cell recording in order to prevent"
wash-out" of the muscarinic response to acetylcholine (ACh) in rat lacrimal gland cells. The …

Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.

ME Gellens, AL George Jr, LQ Chen… - Proceedings of the …, 1992 - National Acad Sciences
The principal voltage-sensitive sodium channel from human heart has been cloned,
sequenced, and functionally expressed. The cDNA, designated hH1, encodes a 2016-amino …

[HTML][HTML] Molecular basis of charge movement in voltage-gated sodium channels

N Yang, AL George, R Horn - Neuron, 1996 - cell.com
Voltage-dependent movement of a sodium channel S4 segment was examined by cysteine
scanning mutagenesis and testing accessibility of the residues to hydrophilic cysteine …

Evidence for voltage-dependent S4 movement in sodium channels

N Yang, R Horn - Neuron, 1995 - cell.com
The mutation R1448C substitutes a cysteine for the outermost arginine in the fourth
transmembrane segment (S4) of domain 4 in skeletal muscle sodium channels. We tested …

Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation

M Chahine, AL George Jr, M Zhou, S Ji, W Sun… - Neuron, 1994 - cell.com
Mutations in the adult human skeletal muscle Na+ channel a subunit cause the disease
paramyotonia congenita. Two paramyotonia congenita mutations, R1448H and R1448C …

[PDF][PDF] Estimating kinetic constants from single channel data

R Horn, K Lange - Biophysical Journal, 1983 - cell.com
The process underlying the opening and closing of ionic channels in biological or artificial
lipid membranes can be modeled kinetically as a time-homogeneous Markov chain. The …

Human γδ+ T cells respond to mycobacterial heat-shock protein

A Haregewoin, G Soman, RC Horn, RW Finberg - Nature, 1989 - nature.com
MOST T cells recognize antigen through the T-cell antigen receptor (TCR) αβ-CD3 complex
on the T-cell surface1. A small percentage of T cells, however, do not express αβ but a …

Stirring up controversy with a voltage sensor paddle

CA Ahern, R Horn - TRENDS in Neurosciences, 2004 - cell.com
Neurons owe their exquisite electrical excitability to voltage-gated ion channels. By creating
and shaping the action potential, these voltage-sensitive proteins supply the neuron with …

Statistical properties of single sodium channels.

R Horn, CA Vandenberg - The Journal of general physiology, 1984 - rupress.org
Single channel currents were obtained from voltage-activated sodium channels in outside-
out patches of tissue-cultured GH3 cells, a clonal line from rat pituitary gland. In membrane …