User profiles for "author:Rakesh Jain"

Rakesh Jain

Massachusetts General Hospital, Harvard Medical School, Carnegie Mellon, Columbia …
Verified email at steele.mgh.harvard.edu
Cited by 226307

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

RK Jain - Science, 2005 - science.org
Solid tumors require blood vessels for growth, and many new cancer therapies are directed
against the tumor vasculature. The widely held view is that these antiangiogenic therapies …

Angiogenesis in cancer and other diseases

P Carmeliet, RK Jain - nature, 2000 - nature.com
Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory
diseases. Concentrated efforts in this area of research are leading to the discovery of a …

Molecular mechanisms and clinical applications of angiogenesis

P Carmeliet, RK Jain - Nature, 2011 - nature.com
Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish
diseases such as cancer. Over the past decade, our understanding of the molecular …

[HTML][HTML] Photodynamic therapy for cancer

DE Dolmans, D Fukumura, RK Jain - Nature reviews cancer, 2003 - nature.com
The therapeutic properties of light have been known for thousands of years, but it was only
in the last century that photodynamic therapy (PDT) was developed. At present, PDT is being …

Understanding the tumor immune microenvironment (TIME) for effective therapy

M Binnewies, EW Roberts, K Kersten, V Chan… - Nature medicine, 2018 - nature.com
The clinical successes in immunotherapy have been both astounding and at the same time
unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical …

Molecular regulation of vessel maturation

RK Jain - Nature medicine, 2003 - nature.com
The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires
recruitment of mural cells, generation of an extracellular matrix and specialization of the …

Delivering nanomedicine to solid tumors

RK Jain, T Stylianopoulos - Nature reviews Clinical oncology, 2010 - nature.com
Recent advances in nanotechnology have offered new hope for cancer detection,
prevention, and treatment. While the enhanced permeability and retention effect has served …

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

P Carmeliet, Y Dor, JM Herbert, D Fukumura… - Nature, 1998 - nature.com
As a result of deprivation of oxygen (hypoxia) and nutrients, the growth and viability of cells
is reduced. Hypoxia-inducible factor (HIF)-1α helps to restore oxygen homeostasis by …

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment

SK Hobbs, WL Monsky, F Yuan… - Proceedings of the …, 1998 - National Acad Sciences
Novel anti-neoplastic agents such as gene targeting vectors and encapsulated carriers are
quite large (approximately 100–300 nm in diameter). An understanding of the functional size …

Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy

RK Jain - Nature medicine, 2001 - nature.com
Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination
therapy | Nature Medicine Skip to main content Thank you for visiting nature.com. You are using …