The past decade has been one of rapid innovation in genome-editing technology. The
opportunity now exists for investigators to manipulate virtually any gene in a diverse range of …

Cleft of lip and palate are most common serial congenital anomalies to affect the orofacial
region. It can occur isolated or together in various combination and/or along with other …

Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …

Background Health system planning requires careful assessment of chronic kidney disease
(CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non …

COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …

Transcription activator-like effector nucleases (TALENs) are a new class of engineered
nucleases that are easier to design to cleave at desired sites in a genome than previous …

The discovery of genetic loci associated with complex diseases has outpaced the
elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide …

Background Human resources for health (HRH) include a range of occupations that aim to
promote or improve human health. The UN Sustainable Development Goals (SDGs) and the …

Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for
five vascular diseases, including coronary artery disease, migraine headache, cervical …

Repair of damaged DNA is essential for maintaining genome integrity and for preventing
genome-instability-associated diseases, such as cancer. By combining proximity labeling …