Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key
Differences With the Adult Disease - PMC Back to Top Skip to main content NIH NLM Logo …

DNA replication− associated mutations are repaired by two components: polymerase
proofreading and mismatch repair. The mutation consequences of disruption to both repair …

Background Gene expression profiling is being widely applied in cancer research to identify
biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful tool for …

Understanding the biology that underlies histologically similar but molecularly distinct
subgroups of cancer has proven difficult because their defining genetic alterations are often …

Purpose To assess the prognostic role of clinical parameters and histology in early
childhood medulloblastoma. Patients and Methods Clinical and histologic data from 270 …

Background Histopathological grading of ependymoma has been controversial with respect
to its reproducibility and clinical significance. In a 3-phase study, we reviewed the pathology …

Multiple independent genomic profiling efforts have recently identified clinically and
molecularly distinct subgroups of ependymoma arising from all three anatomic …

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two
transcriptional subtypes with different clinical outcomes; however, the mechanisms …

In∼ 50% of patients with Hodgkin's lymphoma (HL), the Epstein-Barr virus (EBV), an
oncogenic herpesvirus, is present in tumor cells. After microarray profiling of both HL tumors …

Background Over half of childhood intracranial ependymomas occur in children younger
than 5 years. As an adjuvant treatment, radiotherapy can be effective, but has the potential to …