In an effort to uncover systematic learnings that can be applied to improve compound
survival, an analysis was performed on data from Phase II decisions for 44 programs at …

Complex models of biochemical reaction systems have become increasingly common in the
systems biology literature. The complexity of such models can present a number of …

The combination of drugs is a common practice for enhancing the efficiency of drug
treatment, but selection of the optimal combination and the optimal doses remains a matter …

Background: This white paper arises from two workshops held at the NIH in 2008 and late
2010 with participation from academia, industry and government (http://meetings. nigms. nih …

Mechanistic PKPD models are now advocated not only by academic and industrial
researchers, but also by regulators. A recent development in this area is based on the …

In addition to investigating sexual function in rats that display normal ejaculatory behaviour,
studying rats that are either 'hyposexual'or 'hypersexual'may provide important insights into …

Lack of predictability of clinical efficacy and safety is an important problem facing
pharmaceutical research today. Translational PK–PD has the ability to integrate data …

Obesity and morbid obesity are associated with many physiological changes affecting
pharmacokinetics, such as increased blood volume, cardiac output, splanchnic blood flow …

It is generally accepted that, in conjunction with pharmacokinetics, the first-order rate
constant of target dissociation is a major determinant of the time course and duration of in …

Novel developments in biomarkers discovery are essential in modern health care, notably in
treatment individualization and precision medicine. Clinical metabolomics, which aims to …