Intestinal microbiota in functional bowel disorders: a Rome foundation report

M Simrén, G Barbara, HJ Flint, BMR Spiegel… - Gut, 2013 - gut.bmj.com
It is increasingly perceived that gut host–microbial interactions are important elements in the
pathogenesis of functional gastrointestinal disorders (FGID). The most convincing evidence …

Tegaserod for the treatment of irritable bowel syndrome and chronic constipation

BW Evans, WK Clark, DJ Moore… - Cochrane database of …, 2007 - cochranelibrary.com
Background IBS is a complex disorder that encompasses a wide profile of symptoms. The
symptoms of chronic constipation frequently resemble those of constipation‐predominant …

The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress

CY Francis, J Morris… - Alimentary pharmacology & …, 1997 - Wiley Online Library
Background: The clinical assessment and investigation of irritable bowel syndrome would
be greatly facilitated by the introduction of a simple, easy to use severity scoring system …

Quality of life in irritable bowel syndrome

R Lea, PJ Whorwell - Pharmacoeconomics, 2001 - Springer
Abstract Quality-of-life (QOL) assessment is becoming increasingly important in the
evaluation of the impact of disease and the effect of therapy. This is particularly so for …

Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome

PJ Whorwell, L Altringer, J Morel, Y Bond… - Official journal of the …, 2006 - journals.lww.com
BACKGROUND Probiotic bacteria exhibit a variety of properties, including
immunomodulatory activity, which are unique to a particular strain. Thus, not all species will …

[HTML][HTML] Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

C Eijsbouts, T Zheng, NA Kennedy, F Bonfiglio… - Nature …, 2021 - nature.com
Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …

Altered 5-hydroxytryptamine signaling in patients with constipation-and diarrhea-predominant irritable bowel syndrome

W Atkinson, S Lockhart, PJ Whorwell, B Keevil… - Gastroenterology, 2006 - Elsevier
BACKGROUND & AIMS: Evidence suggests that postprandial platelet-depleted plasma 5-
hydroxytryptamine (5-HT) concentrations may be abnormal in irritable bowel syndrome …

Hypnotherapy in irritable bowel syndrome: a large-scale audit of a clinical service with examination of factors influencing responsiveness

WM Gonsalkorale, LA Houghton… - Official journal of the …, 2002 - journals.lww.com
OBJECTIVES: Hypnotherapy has been shown to be effective in the treatment of irritable
bowel syndrome in a number of previous research studies. This has led to the establishment …

[HTML][HTML] Changes of the human gut microbiome induced by a fermented milk product

P Veiga, N Pons, A Agrawal, R Oozeer, D Guyonnet… - Scientific reports, 2014 - nature.com
The gut microbiota (GM) consists of resident commensals and transient microbes conveyed
by the diet but little is known about the role of the latter on GM homeostasis. Here we show …

First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable …

J Kapeller, LA Houghton, H Mönnikes… - Human molecular …, 2008 - academic.oup.com
Diarrhea predominant irritable bowel syndrome (IBS-D) is a complex disorder related to
dysfunctions in the serotonergic system. As cis-regulatory variants can play a role in the …