In 2009 we reported the fatal case of a toddler who had received codeine after
adenotonsillectomy for obstructive sleep apnea syndrome. The child was an ultra-rapid …

To the Editor: Obstructive sleep apnea is not rare in children with hypertrophic tonsils, and
the common curative procedure is adenotonsillectomy. 1 Codeine is commonly prescribed …

Codeine has been used medicinally since the 1800s as an analgesic and antitussive agent.
Although very few studies have methodically examined the safety of codeine use in the …

Background: Calcineurin inhibition (CNI) is the mainstay of immunosuppressant therapy for
most solid organ transplant patients. High tacrolimus levels are related with acute …

Background There is an increased risk of death due to drug toxicity after release from
incarceration. The purpose of this study was to describe the timing, rate and circumstances …

QUESTION Recently a newborn died from morphine poisoning when hismother used
codeine while breastfeeding. Many patients receive codeine for postlabour pain. Is it safe to …

Background The impact of the prescription opioid public health crisis has been illustrated by
the dramatic increase in opioid-related deaths in North America. We aimed to identify …

OBJECTIVE: To quantify the incidence of central nervous system (CNS) depression in
neonates breastfed by mothers medicated with oxycodone as compared with neonates …

OBJECTIVE: To assess central nervous system depression and other adverse effects in
infants exposed to benzodiazepines through breast milk. STUDY DESIGN: A prospectively …

Fatal opioid toxicity occurred in a developmentally delayed child aged 5 years 9 months who
was inadvertently administered high doses of hydrocodone for a respiratory tract infection …