The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the
characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting …

Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …

Positron emission tomography (PET) and single photon emission computed tomography
(SPECT) can measure striatal dopamine (DA) terminal function in vivo as reflected by DA …

Synaptic dopamine release from embryonic nigral transplants has been monitored in the
striatum of a patient with Parkinson's disease using [11 C]-raclopride positron emission …

Patients suffering from Parkinson's disease (PD) will typically experience a range of motor
and nonmotor symptoms during the course of their illness, each of which will affect a …

This is the first in vivo demonstration of an association between endogenous
neurotransmitter release and conscious experience. Using 11C-raclopride PET we …

Severe dyskinesias during the'off'phases (periods of increased Parkinson's disease (PD)
disability) have been observed following intrastriatal transplantation of human embryonic …

Objective A small group of Parkinson's disease (PD) patients compulsively use
dopaminergic drugs despite causing harmful social, psychological, and physical effects and …

Microglial activation may play a role in the pathogenesis of Huntington's disease (HD).
Using 11C-(R)-PK11195 (PK) positron emission tomography (PET), we investigated …

Despite the major finding of a genetic defect being responsible for the Parkinson's disease
(PD) phenotype in some kindreds with dominantly transmitted PD, the role of inheritance in …