[HTML][HTML] Paracetamol in older people: towards evidence-based dosing?
P Mian, K Allegaert, I Spriet, D Tibboel, M Petrovic - Drugs & aging, 2018 - Springer
Paracetamol is the most commonly used analgesic in older people, and is mainly dosed
according to empirical dosing guidelines. However, the pharmacokinetics and thereby the …
according to empirical dosing guidelines. However, the pharmacokinetics and thereby the …
Developmental pharmacokinetics in neonates: maturational changes and beyond
K Allegaert, P Mian… - Current pharmaceutical …, 2017 - ingentaconnect.com
Background: Effective and safe pharmacotherapy in an individual neonate necessitates
understanding the pharmacokinetic (PK) and pharmacodynamic (PD) properties of a specific …
understanding the pharmacokinetic (PK) and pharmacodynamic (PD) properties of a specific …
Clinical pharmacokinetic studies in pregnant women and the relevance of pharmacometric tools
A Dallmann, P Mian, JV den Anker… - Current …, 2019 - ingentaconnect.com
Background: In clinical pharmacokinetic (PK) studies, pregnant women are significantly
underrepresented because of ethical and legal reasons which lead to a paucity of …
underrepresented because of ethical and legal reasons which lead to a paucity of …
[HTML][HTML] Integration of placental transfer in a fetal–maternal physiologically based pharmacokinetic model to characterize acetaminophen exposure and metabolic …
P Mian, K Allegaert, S Conings, P Annaert… - Clinical …, 2020 - Springer
Abstract Background and Objective Although acetaminophen is frequently used during
pregnancy, little is known about fetal acetaminophen pharmacokinetics. Acetaminophen …
pregnancy, little is known about fetal acetaminophen pharmacokinetics. Acetaminophen …
[HTML][HTML] Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) …
P Mian, JN Van Den Anker, K van Calsteren… - Clinical …, 2020 - Springer
Abstract Background and Objective Little is known about acetaminophen (paracetamol)
pharmacokinetics during pregnancy. The aim of this study was to develop a physiologically …
pharmacokinetics during pregnancy. The aim of this study was to develop a physiologically …
Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis
K Allegaert, P Mian, A Lapillonne… - British journal of …, 2019 - Wiley Online Library
Recent case reports describe an association between maternal paracetamol intake and fetal
ductus arteriosus constriction or closure. To put these cases into perspective and explore …
ductus arteriosus constriction or closure. To put these cases into perspective and explore …
[HTML][HTML] Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review
D van de Vusse, P Mian, S Schoenmakers… - European Journal of …, 2022 - Springer
Purpose Antihypertensive drugs are among the most prescribed drugs during pregnancy.
Methyldopa, labetalol, and nifedipine have been perceived safe to use during pregnancy …
Methyldopa, labetalol, and nifedipine have been perceived safe to use during pregnancy …
[HTML][HTML] The effect of pregnancy and inflammatory bowel disease on the pharmacokinetics of drugs related to inflammatory bowel disease—a systematic literature …
TK Wiersma, MC Visschedijk, NK de Boer… - Pharmaceutics, 2022 - mdpi.com
Due to ethical and practical reasons, a knowledge gap exists on the pharmacokinetics (PK)
of inflammatory bowel disease (IBD)-related drugs in pregnant women with IBD. Before …
of inflammatory bowel disease (IBD)-related drugs in pregnant women with IBD. Before …
[HTML][HTML] Placenta-on-a-Chip as an In Vitro Approach to Evaluate the Physiological and Structural Characteristics of the Human Placental Barrier upon Drug Exposure …
FA Elzinga, B Khalili, DJ Touw, JR Prins… - Journal of Clinical …, 2023 - mdpi.com
Quantification of fetal drug exposure remains challenging since sampling from the placenta
or fetus during pregnancy is too invasive. Currently existing in vivo (eg, cord blood sampling) …
or fetus during pregnancy is too invasive. Currently existing in vivo (eg, cord blood sampling) …
Quantification of acetaminophen and its metabolites in plasma using UPLC-MS: doors open to therapeutic drug monitoring in special patient populations
RB Flint, P Mian, B van der Nagel… - Therapeutic Drug …, 2017 - journals.lww.com
Background: Acetaminophen (APAP, paracetamol) is the most commonly used drug for pain
and fever in both the United States and Europe and is considered safe when used at …
and fever in both the United States and Europe and is considered safe when used at …