The diversity of life is ultimately generated by evolution, and much attention has focused on
the rapid evolution of ecological traits. Yet, the tendency for many ecological traits to instead …

Summary 1 The biases and shortcomings of stepwise multiple regression are well
established within the statistical literature. However, an examination of papers published in …

Warder C. Allee brought attention to the possibility of a positive relationship between
aspects of fitness and population size 50 years ago. Until recently, however, this concept …

Cancers arise owing to the accumulation of mutations in critical genes that alter normal
programmes of cell proliferation, differentiation and death. As the first stage of a systematic …

Cancers arise owing to mutations in a subset of genes that confer growth advantage. The
availability of the human genome sequence led us to propose that systematic resequencing …

Cancer is driven by somatically acquired point mutations and chromosomal rearrangements,
conventionally thought to accumulate gradually over time. Using next-generation …

The unpolarized absorption and circular dichroism spectra of the fundamental vibrational
transitions of the chiral molecule 4-methyl-2-oxetanone are calculated ab initio. Harmonic …

All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the
DNA damage and repair processes to which cancer cells and their precursors have been …

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in …

All cancers carry somatic mutations. A subset of these somatic alterations, termed driver
mutations, confer selective growth advantage and are implicated in cancer development …