Objective: Alterations in reward-related brain function and phenomenological aspects of
positive affect are increasingly examined in the development of major depressive disorder …

The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain
functions and is critically involved in many neuropsychiatric disorders. Here, we present a …

The main psychedelic component of magic mushrooms is psilocybin, which shows promise
as a treatment for depression and other mental disorders. Psychedelic effects are believed …

Exploratory (ie, voxelwise) spatial methods are commonly used in neuroimaging to identify
areas that show an effect when a region-of-interest (ROI) analysis cannot be performed …

Individual variation in physiological responsiveness to stress mediates risk for mental illness
and is influenced by both experiential and genetic factors. Common polymorphisms in the …

Context Serotonin 1A (5-hydroxytryptamine 1A [5-HT 1A]) autoreceptors mediate negative
feedback inhibition of serotonergic neurons and play a critical role in regulating serotonin …

Abstract Variability in serotonin (5-HT) function is associated with individual differences in
normal mood and temperament, as well as psychiatric illnesses, all of which are influenced …

The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of
cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor …

Feedback inhibition of the amygdala via medial prefrontal cortex (mPFC) is an important
component in the regulation of complex emotional behaviors. The functional dynamics of …

The amygdala is critically involved in mediating physiological and behavioral responses to
threat. In particular, neuroimaging research indicates that the amygdala is highly responsive …