Background Infants born very preterm (< 33 weeks) are at increased risk of neurocognitive
deficits. Their neurodevelopmental outcome up to age 8 years can be predicted by neonatal …

The aims of this study were 1) to define normal perinatal maturational changes in proton
metabolite peak-area ratios in two regions of the neonatal brain, the thalamic and …

Studies of the brains of severely birth-asphyxiated infants using proton (1 H) magnetic
resonance spectroscopy (MRS) have shown changes indicating a rise in cerebral lactate …

Although near infrared spectroscopy (NIRS) is primarily used to probe changes in
oxyhaemoglobin (HbO 2) and deoxyhaemoglobin (dHb) concentrations, it has long been …

The use of near-infrared spectroscopy to measure noninvasively changes in the redox state
of cerebral cytochrome oxidase in vivo is controversial. We therefore tested these …

This study investigated the accuracy of prediction of neurodevelopmental outcome at 1 year
using cerebral proton magnetic resonance spectroscopy (MRS) and structured neonatal …

This study tested the hypothesis that mild hypothermia after severe transient hypoxia-
ischemia reduces the subsequent delayed rise in cerebral lactate peak-area ratios as …

Previous studies of the brains of normal infants demonstrated lower lactate (Lac)/choline
(Cho), Lac/creatine (Cr), and Lac/N‐acetylaspartate (Naa) peak‐area ratios in the thalamic …

Background: Guidelines published by the International Liaison Committee for Resuscitation
and by the World Health Organization recommend delaying cord clamping at birth as part of …

Severely birth-asphyxiated human infants develop delayed (“secondary”) cerebral energy
failure, which carries a poor prognosis, during the first few days of life. This study tested the …