Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots
KB Gale, AM Ford, R Repp… - Proceedings of the …, 1997 - National Acad Sciences
Epidemiological evidence has suggested that some pediatric leukemias may be initiated in
utero and, for some pairs of identical twins with concordant leukemia, this possibility has …
utero and, for some pairs of identical twins with concordant leukemia, this possibility has …
Relative frequency and morphology of cancers in carriers of germline TP53 mutations
JM Birch, RD Alston, RJQ McNally, DGR Evans… - Oncogene, 2001 - nature.com
The spectrum and frequency of cancers associated with germline TP53 mutations are
uncertain. To address this issue a cohort of individuals from 28 families with Li-Fraumeni …
uncertain. To address this issue a cohort of individuals from 28 families with Li-Fraumeni …
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia
JL Wiemels, RN Smith, GM Taylor… - Proceedings of the …, 2001 - National Acad Sciences
Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in
the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an …
the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an …
A Lack of a Functional NAD(P)H:Quinone Oxidoreductase Allele Is Selectively Associated with Pediatric Leukemias That Have MLL Fusions
JL Wiemels, A Pagnamenta, GM Taylor, OB Eden… - Cancer research, 1999 - AACR
Rearrangements and fusion of the MLL gene with various alternative partner genes occur
in∼ 80% of infant leukemias and are acquired during fetal hemopoiesis in utero. Similar …
in∼ 80% of infant leukemias and are acquired during fetal hemopoiesis in utero. Similar …
Molecular tracking of leukemogenesis in a triplet pregnancy
The occurrence of childhood acute lymphoblastic leukemia (ALL) in 2 of 3 triplets provided a
unique opportunity for the investigation of leukemogenesis and the natural history of ALL …
unique opportunity for the investigation of leukemogenesis and the natural history of ALL …
Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: Results of the risk‐stratified …
FGH Hill, S Richards, B Gibson, I Hann… - British journal of …, 2004 - Wiley Online Library
Concern about late adverse effects of cranial radiotherapy (XRT) has led to alternative
approaches to eliminate leukaemia from the central nervous system (CNS) in childhood …
approaches to eliminate leukaemia from the central nervous system (CNS) in childhood …
Leptomeningeal melanoma in childhood
GWJ Makin, OB Eden, LS Lashford… - … Journal of the …, 1999 - Wiley Online Library
BACKGROUND Malignant melanoma (MM) is one of the least common types of childhood
cancer, accounting for less than 1% of all pediatric malignancies. Neurocutaneous …
cancer, accounting for less than 1% of all pediatric malignancies. Neurocutaneous …
Temporal increases in the incidence of childhood solid tumors seen in Northwest England (1954–1998) are likely to be real
RJQ McNally, AM Kelsey, DP Cairns… - … Journal of the …, 2001 - Wiley Online Library
BACKGROUND There has been speculation that increasing trends in incidence of
childhood central nervous system tumors and infant neuroblastoma in the United States …
childhood central nervous system tumors and infant neuroblastoma in the United States …
Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1* 0201
G Malcolm Taylor, S Dearden, P Ravetto… - Human molecular …, 2002 - academic.oup.com
In a previous study, we obtained preliminary evidence in a small series of patients (n= 63)
suggesting that susceptibility to childhood common acute lymphoblastic leukaemia (c-ALL) …
suggesting that susceptibility to childhood common acute lymphoblastic leukaemia (c-ALL) …
Geographical and ecological analyses of childhood acute leukaemias and lymphomas in north‐west England
RJQ McNally, RD Alston, DP Cairns… - British journal of …, 2003 - Wiley Online Library
Childhood leukaemias and lymphomas have been associated with exposure to
environmental factors, including infections, which show geographical variation. This study …
environmental factors, including infections, which show geographical variation. This study …