A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs

AJ Winter, SD Comis, MP Osborne… - Infection and …, 1997 - Am Soc Microbiol
We investigated the roles of pneumolysin and neuraminidase in the pathogenesis of
deafness and cochlear damage during experimental pneumococcal meningitis …

Macrolides in the management of streptococcal pharyngitis/tonsillitis

MJ Tarlow - The Pediatric infectious disease journal, 1997 - journals.lww.com
The most frequent bacterial cause of pharyngitis/tonsillitis, a common infection in children, is
group A beta-hemolytic streptococci. Prevention of acute rheumatic fever is the principal …

Diagnosis of primary human herpesvirus 6 and 7 infections in febrile infants by polymerase chain reaction

DA Clark, IM Kidd, KE Collingham, M Tarlow… - Archives of disease in …, 1997 - adc.bmj.com
Primary human herpesvirus 6 (HHV-6) and 7 (HHV-7) infections were identified in febrile
children by qualitative and quantitative polymerase chain reaction (PCR) assays. Diagnosis …

Otoacoustic emissions as a screening test for hearing impairment in children recovering from acute bacterial meningitis

MP Richardson, TJ Williamson, A Reid, MJ Tarlow… - …, 1998 - publications.aap.org
Objectives. To study the efficacy of otoacoustic emissions (OAEs) as a screening test for
hearing impairment in children with acute bacterial meningitis. Hearing tests were performed …

Possible involvement of nitric oxide in the sensorineural hearing loss of bacterial meningitis

FR Amaee, SD Comis, MP Osborne, S Drew… - Acta oto …, 1997 - Taylor & Francis
Amaee FR, Comis SD, Osborne MP, Drew S, Tarlow MJ. Possible involvement of nitric oxide
in the sensorineural hearing loss of bacteria! meningitis. Acta Otolaryngol (Stockh) 1997; …

Temperature-dependent modulation of lipopolysaccharide-induced interleukin-1 beta and tumor necrosis factor alpha expression in cultured human astroglial cells by …

S Velasco, M Tarlow, K Olsen, JW Shay… - The Journal of …, 1991 - Am Soc Clin Investig
In bacterial meningitis, LPS induces production in cerebrospinal fluid of the cytokines IL-1
beta and tumor necrosis factor alpha (TNF alpha), which are the principle mediators of …

Otitis media: pathogenesis and medical sequelae

M Tarlow - Ear, nose & throat journal, 1998 - search.proquest.com
Eustachian tube abnormalities are a primary determinant of otitis media. Other determinants
include viral infections and local and systemic immune deficiencies, which predispose to …

Prevention of perinatal transmission of hepatitis B virus (HB V): A comparison of two prophylactic schedules

SM Wheeley, PT Jackson, EH Boxall… - Journal of medical …, 1991 - Wiley Online Library
Perinatal transmission of hepatitis B virus (HBV) from HBsAg carrier mothers who were
HBeAg+, antiHBe+, or negative for both HBe markers, was interrupted using either 4 doses …

Future indications for macrolides

MJ Tarlow, SL Block, J Harris… - The Pediatric infectious …, 1997 - journals.lww.com
The antimicrobial spectrum of azithromycin and clarithromycin suggests a number of further
uses for these newer macrolides. Favorable clinical and bacteriologic responses have been …

Ultrastructural damage to the organ of corti during acute experimental Escherichia coli and pneumococcal meningitis in guinea pigs

A Winter, S Marwick, M Osborne, S Comis… - Acta oto …, 1996 - Taylor & Francis
Experimental meningitis was induced in 16 pigmented guinea pigs by subarachnoid
inoculation of mid log-phase 1 109 E. coli K-12 (n= 8) or 5 107 Streptococcus pneumoniae …