A novel multiple-stage antimalarial agent that inhibits protein synthesis

B Baragaña, I Hallyburton, MCS Lee, NR Norcross… - Nature, 2015 - nature.com
There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and
novel modes of action, to widen the scope of treatment and to overcome emerging drug …

[HTML][HTML] Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

NJ White, EA Ashley, J Recht, MJ Delves, A Ruecker… - Malaria journal, 2014 - Springer
Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in
falciparum malaria include measurement of the duration of gametocytaemia, the rate of …

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

T Paquet, C Le Manach, DG Cabrera… - Science translational …, 2017 - science.org
As part of the global effort toward malaria eradication, phenotypic whole-cell screening
revealed the 2-aminopyridine class of small molecules as a good starting point to develop …

Quinolone-3-diarylethers: a new class of antimalarial drug

A Nilsen, AN LaCrue, KL White, IP Forquer… - Science translational …, 2013 - science.org
The goal for developing new antimalarial drugs is to find a molecule that can target multiple
stages of the parasite's life cycle, thus impacting prevention, treatment, and transmission of …

Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs

MJ Delves, A Ruecker, U Straschil… - Antimicrobial agents …, 2013 - Am Soc Microbiol
It is the mature gametocytes of Plasmodium that are solely responsible for parasite
transmission from the mammalian host to the mosquito. They are therefore a logical target …

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

GA Biagini, N Fisher, AE Shone… - Proceedings of the …, 2012 - National Acad Sciences
There is an urgent need for new antimalarial drugs with novel mechanisms of action to
deliver effective control and eradication programs. Parasite resistance to all existing …

[HTML][HTML] The antimalarial screening landscape—looking beyond the asexual blood stage

S Yahiya, A Rueda-Zubiaurre, MJ Delves… - Current Opinion in …, 2019 - Elsevier
In recent years, the research agenda to tackle global morbidity and mortality from malaria
disease has shifted towards innovation, in the hope that efforts at the frontiers of scientific …

Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions

MJ Delves, U Straschil, A Ruecker, C Miguel-Blanco… - Nature protocols, 2016 - nature.com
The prevention of parasite transmission from the human host to the mosquito has been
recognized as a vital tool for malaria eradication campaigns. However, transmission …

[HTML][HTML] A high throughput screen for next-generation leads targeting malaria parasite transmission

MJ Delves, C Miguel-Blanco, H Matthews… - Nature …, 2018 - nature.com
Spread of parasite resistance to artemisinin threatens current frontline antimalarial
therapies, highlighting the need for new drugs with alternative modes of action. Since only …

Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy

B Baragaña, NR Norcross, C Wilson… - Journal of medicinal …, 2016 - ACS Publications
The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-
carboxamides are described. This series was identified from a phenotypic screen against …