A side order of stem cells: the SP phenotype

GA Challen, MH Little - Stem cells, 2006 - academic.oup.com
A defining property of murine hematopoietic stem cells (HSCs) is low fluorescence after
staining with Hoechst 33342 and Rhodamine 123. These dyes have proven to be …

Mammalian kidney development: principles, progress, and projections

MH Little, AP McMahon - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …

A clinical overview of WT1 gene mutations

M Little, C Wells - Human mutation, 1997 - Wiley Online Library
Mutations in the WT1 gene ere anticipated to explain the genetic basis of the childhood
kidney cancer, Wilms' tumour (WT). Six years on, we revie 100 reports of intragenic WT1 …

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

M Takasato, PX Er, HS Chiu, B Maier, GJ Baillie… - Nature, 2015 - nature.com
The human kidney contains up to 2 million epithelial nephrons responsible for blood
filtration. Regenerating the kidney requires the induction of the more than 20 distinct cell …

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

M Takasato, PX Er, M Becroft, JM Vanslambrouck… - Nature cell …, 2014 - nature.com
With the prevalence of end-stage renal disease rising 8% per annum globally, there is an
urgent need for renal regenerative strategies. The kidney is a mesodermal organ that …

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation

KT Lawlor, JM Vanslambrouck, JW Higgins… - Nature materials, 2021 - nature.com
Directed differentiation of human pluripotent stem cells to kidney organoids brings the
prospect of drug screening, disease modelling and the generation of tissue for renal …

Mice Lacking the Vascular Endothelial Growth Factor-B Gene (Vegfb) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From …

D Bellomo, JP Headrick, GU Silins… - Circulation …, 2000 - Am Heart Assoc
Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of
blood vessel growth during development and disease and a strong candidate for angiogenic …

[PDF][PDF] Renal subcapsular transplantation of PSC-derived kidney organoids induces neo-vasculogenesis and significant glomerular and tubular maturation in vivo

CW van den Berg, L Ritsma, MC Avramut, LE Wiersma… - Stem cell reports, 2018 - cell.com
Human pluripotent stem cell (hPSC)-derived kidney organoids may facilitate disease
modeling and the generation of tissue for renal replacement. Long-term application …

Generation of kidney organoids from human pluripotent stem cells

M Takasato, PX Er, HS Chiu, MH Little - Nature protocols, 2016 - nature.com
The human kidney develops from four progenitor populations—nephron progenitors,
ureteric epithelial progenitors, renal interstitial progenitors and endothelial progenitors …

[HTML][HTML] Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment

K Georgas, B Rumballe, MT Valerius, HS Chiu… - Developmental …, 2009 - Elsevier
While nephron formation is known to be initiated by a mesenchyme-to-epithelial transition of
the cap mesenchyme to form a renal vesicle (RV), the subsequent patterning of the nephron …