The Simcyp® population-based absorption, distribution, metabolism and excretion simulator
is a platform and database for 'bottom-up'mechanistic modelling and simulation of the …

The bioavailability of drugs from oral formulations is influenced by many physiological
factors including gastrointestinal fluid composition, pH and dynamics, transit and motility …

An increasing number of failures in clinical stages of drug development have been related to
the effects of candidate drugs in a sub-group of patients rather than theaverage'person …

Despite a lower content of many drug metabolising enzymes in the intestinal epithelium
compared to the liver (eg intestinal CYP3A abundance in the intestine is 1% that of the liver) …

Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

This work provides a perspective on the qualification and verification of physiologically
based pharmacokinetic (PBPK) platforms/models intended for regulatory submission based …

In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and
degradation. A current lack of consensus on values of the in vivo turnover half-lives of …

There is a renewed surge of interest in applications of physiologically-based
pharmacokinetic (PBPK) models by the pharmaceutical industry and regulatory agencies …

AIM: To predict the magnitude of metabolic drug–drug interaction (mDDI) between triazolam
and diltiazem and its primary metabolite N-desmethyldiltiazem (MA). METHODS: Relevant in …

Bioavailability of orally administered drugs can be influenced by a number of factors
including release from the formulation, dissolution, stability in the gastrointestinal (GI) …