[HTML][HTML] Constipation in children

NA Afzal, MP Tighe, MA Thomson - Italian Journal of Pediatrics, 2011 - Springer
Constipation remains a frequent presentation to paediatricians, with significant health
resource implications. We present a practical guide to the management of paediatric …

Current pharmacological management of gastro-esophageal reflux in children: an evidence-based systematic review

MP Tighe, NA Afzal, A Bevan, RM Beattie - Pediatric Drugs, 2009 - Springer
Gastro-esophageal reflux (GER) is a common phenomenon, characterized by the
regurgitation of the gastric contents into the esophagus. Gastro-esophageal reflux disease …

[PDF][PDF] Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs

JE Moyron-Quiroz, J Rangel-Moreno, L Hartson… - Immunity, 2006 - cell.com
Secondary lymphoid organs (SLOs) promote primary immune responses by recruiting naive
lymphocytes and activated APCs. However, their role in the persistence or responsiveness …

Impact of prior dengue virus infection on Zika virus infection during pregnancy in marmosets

IJ Kim, MP Tighe, MJ Clark, GD Gromowski… - Science Translational …, 2023 - science.org
Zika virus (ZIKV) infection during pregnancy causes severe developmental defects in
newborns, termed congenital Zika syndrome (CZS). Factors contributing to a surge in ZIKV …

Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in mice

ML Garcia-Hernandez, H Hamada… - The Journal of …, 2010 - journals.aai.org
In vitro generated OVA-specific IL-17–producing CD8 T effector cells (Tc17) from OT-1 mice,
adoptively transferred into B16-OVA tumor-bearing mice, controlled tumor growth in early …

Functional abdominal pain: what clinicians need to know

ET Andrews, RM Beattie, MP Tighe - Archives of disease in childhood, 2020 - adc.bmj.com
Abdominal pain in childhood is extremely common and presents frequently to both primary
and secondary care, with many children having recurrent pain which impacts on daily …

Live attenuated influenza vaccine (LAIV) impacts innate and adaptive immune responses

PA Lanthier, GE Huston, A Moquin, SM Eaton… - Vaccine, 2011 - Elsevier
Influenza A infection induces a massive inflammatory response in the lungs that leads to
significant illness and increases the susceptibility to secondary bacterial pneumonia. The …

[HTML][HTML] Efficacy of an inactivated Zika vaccine against virus infection during pregnancy in mice and marmosets

IJ Kim, PA Lanthier, MJ Clark, RA De La Barrera… - npj Vaccines, 2022 - nature.com
Zika virus (ZIKV) is a mosquito-borne arbovirus that can cause severe congenital birth
defects. The utmost goal of ZIKV vaccines is to prevent both maternal-fetal infection and …

Perometry versus simulated circumferential tape measurement for the detection of breast cancer-related lymphedema

F Sun, A Hall, MP Tighe, CL Brunelle… - Breast cancer research …, 2018 - Springer
Purpose Despite increasing emphasis on screening and early intervention for breast cancer-
related lymphedema (BCRL), there is marked heterogeneity in diagnostic methodology …

Hirschsprung's disease

A Arshad, C Powell, MP Tighe - Bmj, 2012 - bmj.com
A 3 year old boy is brought to his general practitioner again by his worried mother. She is
concerned that he remains constipated despite trying a third different laxative. Further history …