Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …

Objectives Procedures for controlling the false positive rate when performing many
hypothesis tests are commonplace in health and medical studies. Such procedures, most …

Abstract Bacillus Calmette–Guérin (BCG) has been used to treat non-muscle-invasive
bladder cancer for more than 30 years. It is one of the most successful biotherapies for …

Abstract The National Kidney Foundation's Kidney Disease Outcomes Quality Initiative
(KDOQI) has provided evidence-based guidelines for hemodialysis vascular access since …

Abstract As of 10 April 2020, New York State had 180,458 cases of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and 9,385 reported deaths. Patients with cancer …

Background Many patients with hypertension have inadequate control of their blood
pressure. Improving the treatment of hypertension requires an understanding of the ways in …

The core particle (CP) of the yeast proteasome is composed of four heptameric rings of
subunits arranged in a hollow, barrel-like structure. We report that the CP is autoinhibited by …

The proteasome consists of a 20S proteolytic core particle (CP) and a 19S regulatory
particle (RP), which selects ubiquitinated substrates for translocation into the CP. An eight …

Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the
functional effector or memory T cell states,,,,–. Here we identify the nuclear factor TOX as a …

PURPOSE: To compare non-contrast-enhanced computed tomography (CT) and
intravenous urography (IVU) in the evaluation of patients who present with acute flank pain …