Diagnostic utility of rapid sequencing in critically ill infants: a systematic review and meta-analysis
F Xiao, K Yan, M Tang, X Ji, L Hu, L Yang… - Expert Review of …, 2022 - Taylor & Francis
Background Genetic disorders are a major cause of death in critically ill infants. Several
studies have assessed the diagnostic yield of rapid genomic sequencing in critically ill …
studies have assessed the diagnostic yield of rapid genomic sequencing in critically ill …
[HTML][HTML] Clinical and genetic spectrum of a large cohort of children with epilepsy in China
L Yang, Y Kong, X Dong, L Hu, Y Lin, X Chen, Q Ni… - Genetics in …, 2019 - Elsevier
Purpose Genetic diagnosis for children suffering from epilepsy has important implications for
treatment, prognosis, and development of precision medicine strategies. Methods We …
treatment, prognosis, and development of precision medicine strategies. Methods We …
[HTML][HTML] The Bacteriophage EF-P29 Efficiently Protects against Lethal Vancomycin-Resistant Enterococcus faecalis and Alleviates Gut Microbiota Imbalance in a …
M Cheng, J Liang, Y Zhang, L Hu, P Gong… - Frontiers in …, 2017 - frontiersin.org
Enterococcus faecalis is becoming an increasingly important opportunistic pathogen
worldwide, especially because it can cause life-threatening nosocomial infections. Treating …
worldwide, especially because it can cause life-threatening nosocomial infections. Treating …
[HTML][HTML] Risk factors associated with mortality of COVID-19 in 3125 counties of the United States
T Tian, J Zhang, L Hu, Y Jiang, C Duan, Z Li… - Infectious diseases of …, 2021 - Springer
Background The number of cumulative confirmed cases of COVID-19 in the United States
has risen sharply since March 2020. A county health ranking and roadmaps program has …
has risen sharply since March 2020. A county health ranking and roadmaps program has …
[HTML][HTML] LysGH15 kills Staphylococcus aureus without being affected by the humoral immune response or inducing inflammation
The lysin LysGH15, derived from the staphylococcal phage GH15, exhibits a wide lytic
spectrum and highly efficient lytic activity against methicillin-resistant Staphylococcus aureus …
spectrum and highly efficient lytic activity against methicillin-resistant Staphylococcus aureus …
Association between expanded genomic sequencing combined with hearing screening and detection of hearing loss among newborns in a neonatal intensive care …
Y Zhu, L Hu, L Yang, L Wang, Y Lu, X Dong… - JAMA Network …, 2022 - jamanetwork.com
Importance Hearing loss is a global social burden. Early identification of hearing loss missed
by newborn hearing screening tests in the neonatal intensive care unit is crucial. Objective …
by newborn hearing screening tests in the neonatal intensive care unit is crucial. Objective …
Combination therapy of LysGH15 and apigenin as a new strategy for treating pneumonia caused by Staphylococcus aureus
F Xia, X Li, B Wang, P Gong, F Xiao… - Applied and …, 2016 - Am Soc Microbiol
Pneumonia is one of the most prevalent Staphylococcus aureus-mediated diseases, and the
treatment of this infection is becoming challenging due to the emergence of multidrug …
treatment of this infection is becoming challenging due to the emergence of multidrug …
[HTML][HTML] Endolysin LysEF-P10 shows potential as an alternative treatment strategy for multidrug-resistant Enterococcus faecalis infections
M Cheng, Y Zhang, X Li, J Liang, L Hu, P Gong… - Scientific reports, 2017 - nature.com
Phage-derived lysins can hydrolyse bacterial cell walls and show great potential for
combating Gram-positive pathogens. In this study, the potential of LysEF-P10, a new lysin …
combating Gram-positive pathogens. In this study, the potential of LysEF-P10, a new lysin …
[HTML][HTML] Characterization of Enterococcus faecium bacteriophage IME-EFm5 and its endolysin LysEFm5
P Gong, M Cheng, X Li, H Jiang, C Yu, N Kahaer, J Li… - Virology, 2016 - Elsevier
Due to the worldwide prevalence of antibiotic resistant strains, phages therapy has been
revitalized recently. In this study, an Enterococcus faecium phage named IME-EFm5 was …
revitalized recently. In this study, an Enterococcus faecium phage named IME-EFm5 was …
[HTML][HTML] Combining metagenomic sequencing with whole exome sequencing to optimize clinical strategies in neonates with a suspected central nervous system …
M Ge, M Gan, K Yan, F Xiao, L Yang, B Wu… - Frontiers in cellular …, 2021 - frontiersin.org
Objectives Central nervous system (CNS) infection has a high incidence and mortality in
neonates, but conventional tests are time-consuming and have a low sensitivity. Some rare …
neonates, but conventional tests are time-consuming and have a low sensitivity. Some rare …