The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)
statement, published in 2009, was designed to help systematic reviewers transparently …

Systematic reviews should build on a protocol that describes the rationale, hypothesis, and
planned methods of the review; few reviews report whether a protocol exists. Detailed, well …

Protocols of systematic reviews and meta-analyses allow for planning and documentation of
review methods, act as a guard against arbitrary decision making during review conduct …

The methods and results of systematic reviews should be reported in sufficient detail to allow
users to assess the trustworthiness and applicability of the review findings. The Preferred …

Assessment of risk of bias is regarded as an essential component of a systematic review on
the effects of an intervention. The most commonly used tool for randomised trials is the …

Background In systematic reviews and meta-analyses, time-to-event outcomes are most
appropriately analysed using hazard ratios (HRs). In the absence of individual patient data …

Importance Systematic reviews and meta-analyses of individual participant data (IPD) aim to
collect, check, and reanalyze individual-level data from all studies addressing a particular …

Background Pre-eclampsia is a major cause of mortality and morbidity during pregnancy
and childbirth. Antiplatelet agents, especially low-dose aspirin, might prevent or delay pre …

The use of meta-analyses or overviews to combine formally the results of related
randomised clinical trials is becoming increasingly common. However the distinction …

Systematic reviews and meta-analyses that obtain original research data on individual
participants enrolled in trials have been described as the gold standard of review. However …