Breast cancer starts as a local disease, but it can metastasize to the lymph nodes and distant
organs. At primary diagnosis, prognostic markers are used to assess whether the transition …

Therapies for patients with cancer have changed gradually over the past decade, moving
away from the administration of broadly acting cytotoxic drugs towards the use of more-specific …

… For example, necrotic Jurkat T-lymphocyte cells (derived from a patient with T cell leukemia)
alone released minimal levels of ctDNA, but coculture with macrophage cell lines caused a …

Background A more accurate means of prognostication in breast cancer will improve the
selection of patients for adjuvant systemic therapy. Methods Using microarray analysis to …

… d, Enlarged portion from a containing a group of co-regulated genes that are the molecular
reflection of extensive lymphocytic infiltrate, and comprise a set of genes expressed in T and …

Background The 70-gene signature test (MammaPrint) has been shown to improve
prediction of clinical outcome in women with early-stage breast cancer. We sought to provide …

The AACR Project GENIE is an international data-sharing consortium focused on generating
an evidence base for precision cancer medicine by integrating clinical-grade cancer …

Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue"
disease subtypes. However, the extent to which genomic signatures are shared across tissues …

Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors. …

Based on the hypothesis that features of the molecular program of normal wound healing
might play an important role in cancer metastasis, we previously identified consistent features …