Summary Background In April, 2020, clinicians in the UK observed a cluster of children with
unexplained inflammation requiring admission to paediatric intensive care units (PICUs). We …

Background Paediatric acute respiratory distress syndrome (PARDS) is associated with high
mortality in children, but until recently no paediatric-specific diagnostic criteria existed. The …

Methods| Wecollectedfollow-updataforthepreviouslypublished multicenter national critical
care cohort admitted to the hospital prior to May 10, 2020. 6 Data from critical care …

Objectives: To study the prevalence, evolution, and clinical factors associated with acute
kidney injury in children admitted to PICUs with pediatric inflammatory multisystem …

Importance The optimal first-line mode of noninvasive respiratory support following
extubation of critically ill children is not known. Objective To evaluate the noninferiority of …

A 3-month-old boy presented with a 3-hour history of a neck lump and difficulty breathing
after 5 days of fever and reduced feeding. Pneumomediastinum with subcutaneous …

Rationale: Few data exist to guide early adjunctive therapy use in pediatric acute respiratory
distress syndrome (PARDS). Objectives: To describe contemporary use of adjunctive …

Since the declaration of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic, 1 a small percentage of children with coronavirus disease 2019 (COVID-19) …

OBJECTIVES: To 1) analyze the short-term biochemical improvements and clinical
outcomes following treatment of children with post-severe acute respiratory syndrome …

Background The optimal target for systemic oxygenation in critically ill children is unknown.
Liberal oxygenation is widely practiced, but has been associated with harm in paediatric …