Mechanisms of stress in the brain
The brain is the central organ involved in perceiving and adapting to social and physical
stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to …
stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to …
[HTML][HTML] Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex
BS McEwen, C Nasca, JD Gray - Neuropsychopharmacology, 2016 - nature.com
The hippocampus provided the gateway into much of what we have learned about stress
and brain structural and functional plasticity, and this initial focus has expanded to other …
and brain structural and functional plasticity, and this initial focus has expanded to other …
Natural and TGF-β–induced Foxp3+ CD4+ CD25+ regulatory T cells are not mirror images of each other
DA Horwitz, SG Zheng, JD Gray - Trends in immunology, 2008 - cell.com
Foxp3+ CD4+ CD25+ regulatory cell (Treg) subsets that maintain immunologic homeostasis
have been considered to be a homogeneous population of naturally occurring, thymus …
have been considered to be a homogeneous population of naturally occurring, thymus …
Natural and induced CD4+ CD25+ cells educate CD4+ CD25− cells to develop suppressive activity: the role of IL-2, TGF-β, and IL-10
SG Zheng, JH Wang, JD Gray, H Soucier… - The Journal of …, 2004 - journals.aai.org
Abstract Thymus-derived, natural CD4+ CD25+ regulatory T cells can educate peripheral
CD4+ CD25− cells to develop suppressive activity by poorly understood mechanisms. TGF …
CD4+ CD25− cells to develop suppressive activity by poorly understood mechanisms. TGF …
Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients
TR Franklin, PD Acton, JA Maldjian, JD Gray… - Biological …, 2002 - Elsevier
Background: Structural deficiencies within limbic and prefrontal regions may contribute to
the characteristic drug-seeking and drug-taking behaviors that prevail in persons dependent …
the characteristic drug-seeking and drug-taking behaviors that prevail in persons dependent …
IL-2 is essential for TGF-β to convert naive CD4+ CD25− cells to CD25+ Foxp3+ regulatory T cells and for expansion of these cells
SG Zheng, J Wang, P Wang, JD Gray… - The Journal of …, 2007 - journals.aai.org
IL-2 and TGF-β both have important roles in the induction and maintenance of immunologic
tolerance, but whether these cytokines act separately or together to achieve this effect is …
tolerance, but whether these cytokines act separately or together to achieve this effect is …
A role for TGF-β in the generation and expansion of CD4+ CD25+ regulatory T cells from human peripheral blood
S Yamagiwa, JD Gray, S Hashimoto… - The Journal of …, 2001 - journals.aai.org
An elusive goal in transplanting organs across histocompatibility barriers has been the
induction of specific tolerance to avoid graft rejection. A considerable body of evidence …
induction of specific tolerance to avoid graft rejection. A considerable body of evidence …
Generation ex vivo of TGF-β-producing regulatory T cells from CD4+ CD25− precursors
SG Zheng, JD Gray, K Ohtsuka… - The Journal of …, 2002 - journals.aai.org
Previously we reported that TGF-β has an important role in the generation and expansion of
human “professional” CD4+ CD25+ regulatory T cells in the periphery that have a cytokine …
human “professional” CD4+ CD25+ regulatory T cells in the periphery that have a cytokine …
TGF-β requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+ CD25+ regulatory cells
Although positive CD28 costimulation is needed for the generation of natural CD4+ CD25+
regulatory T cells, we report that negative CTLA-4 costimulation is necessary for generating …
regulatory T cells, we report that negative CTLA-4 costimulation is necessary for generating …
[HTML][HTML] Recognizing resilience: Learning from the effects of stress on the brain
BS McEwen, JD Gray, C Nasca - Neurobiology of stress, 2015 - Elsevier
As the central organ of stress and adaptation to stressors, the brain plays a pivotal role in
behavioral and physiological responses that may lead to successful adaptation or to …
behavioral and physiological responses that may lead to successful adaptation or to …