Mechanisms of stress in the brain

BS McEwen, NP Bowles, JD Gray, MN Hill… - Nature …, 2015 - nature.com
The brain is the central organ involved in perceiving and adapting to social and physical
stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to …

[HTML][HTML] Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex

BS McEwen, C Nasca, JD Gray - Neuropsychopharmacology, 2016 - nature.com
The hippocampus provided the gateway into much of what we have learned about stress
and brain structural and functional plasticity, and this initial focus has expanded to other …

Natural and TGF-β–induced Foxp3+ CD4+ CD25+ regulatory T cells are not mirror images of each other

DA Horwitz, SG Zheng, JD Gray - Trends in immunology, 2008 - cell.com
Foxp3+ CD4+ CD25+ regulatory cell (Treg) subsets that maintain immunologic homeostasis
have been considered to be a homogeneous population of naturally occurring, thymus …

Natural and induced CD4+ CD25+ cells educate CD4+ CD25− cells to develop suppressive activity: the role of IL-2, TGF-β, and IL-10

SG Zheng, JH Wang, JD Gray, H Soucier… - The Journal of …, 2004 - journals.aai.org
Abstract Thymus-derived, natural CD4+ CD25+ regulatory T cells can educate peripheral
CD4+ CD25− cells to develop suppressive activity by poorly understood mechanisms. TGF …

Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients

TR Franklin, PD Acton, JA Maldjian, JD Gray… - Biological …, 2002 - Elsevier
Background: Structural deficiencies within limbic and prefrontal regions may contribute to
the characteristic drug-seeking and drug-taking behaviors that prevail in persons dependent …

IL-2 is essential for TGF-β to convert naive CD4+ CD25− cells to CD25+ Foxp3+ regulatory T cells and for expansion of these cells

SG Zheng, J Wang, P Wang, JD Gray… - The Journal of …, 2007 - journals.aai.org
IL-2 and TGF-β both have important roles in the induction and maintenance of immunologic
tolerance, but whether these cytokines act separately or together to achieve this effect is …

A role for TGF-β in the generation and expansion of CD4+ CD25+ regulatory T cells from human peripheral blood

S Yamagiwa, JD Gray, S Hashimoto… - The Journal of …, 2001 - journals.aai.org
An elusive goal in transplanting organs across histocompatibility barriers has been the
induction of specific tolerance to avoid graft rejection. A considerable body of evidence …

Generation ex vivo of TGF-β-producing regulatory T cells from CD4+ CD25− precursors

SG Zheng, JD Gray, K Ohtsuka… - The Journal of …, 2002 - journals.aai.org
Previously we reported that TGF-β has an important role in the generation and expansion of
human “professional” CD4+ CD25+ regulatory T cells in the periphery that have a cytokine …

TGF-β requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+ CD25+ regulatory cells

SG Zheng, JH Wang, W Stohl, KS Kim… - The Journal of …, 2006 - journals.aai.org
Although positive CD28 costimulation is needed for the generation of natural CD4+ CD25+
regulatory T cells, we report that negative CTLA-4 costimulation is necessary for generating …

[HTML][HTML] Recognizing resilience: Learning from the effects of stress on the brain

BS McEwen, JD Gray, C Nasca - Neurobiology of stress, 2015 - Elsevier
As the central organ of stress and adaptation to stressors, the brain plays a pivotal role in
behavioral and physiological responses that may lead to successful adaptation or to …