The design, structure, and therapeutic application of matrix metalloproteinase inhibitors

JW Skiles, NC Gonnella, AY Jeng - Current medicinal …, 2001 - ingentaconnect.com
Matrix metalloproteinases (MMPs) are a family of zinc-containing enzymes involved in the
degradation and remodeling of extracellular matrix proteins. The activities of these enzymes …

The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors

JW Skiles, NC Gonnella, AY Jeng - Current medicinal …, 2004 - ingentaconnect.com
Matrix metalloproteinases (MMPs) are a family of zinc-containing enzymes involved in the
degradation and remodeling of extracellular matrix proteins. Under normal physiological …

Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab

…, JL Weinstein, J Kanter, J Skiles… - Pediatric blood & …, 2013 - Wiley Online Library
Background Hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening
hyperinflammatory syndrome that remains difficult to treat. Even with current standard HLH …

Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo-and dipyridodiazepinones

KD Hargrave, JR Proudfoot, KG Grozinger… - Journal of medicinal …, 1991 - ACS Publications
Novel pyrido [2, 3-¿>][l, 4] benzodiazepinones (I), pyrido [2, 3-b][1, 5] benzodiazepinones (II),
and dipyrido [3, 2-b: 2', 3'-e][l, 4] diazepinones (III) were found to inhibit human …

The National Physicians Cooperative: transforming fertility management in the cancer setting and beyond

BM Smith, FE Duncan, L Ataman, K Smith… - Future …, 2018 - Future Medicine
Once unimaginable, fertility management is now a nationally established part of cancer care
in institutions, from academic centers to community hospitals to private practices. Over the …

Patterns and severity of vincristine‐induced peripheral neuropathy in children with acute lymphoblastic leukemia

…, EM Wells, RH Ho, J Skiles… - Journal of the …, 2015 - Wiley Online Library
Vincristine, a critical component of combination chemotherapy treatment for pediatric acute
lymphoblastic leukemia (ALL), can lead to vincristine‐induced peripheral neuropathy …

Spiro indolinone beta-lactams, inhibitors of poliovirus and rhinovlrus 3C-proteinases

JW Skiles, D McNeil - Tetrahedron letters, 1990 - Elsevier
SPIRO INDOLINONE BETA-LACTAMS, INHIBITORS OF POLIOVIRUS AND RHINOVIRUS
3GPROTEINASES Page 1 oo4o-4039190 s3.00 + .oo Pcl.gamonPTels pk SPIRO INDOLINONE …

Transcatheter aortic valve replacement in low-risk patients with bicuspid aortic valve stenosis

JK Forrest, B Ramlawi, GM Deeb, F Zahr… - JAMA …, 2021 - jamanetwork.com
Importance The outcomes of transcatheter aortic valve replacement (TAVR) in low-risk
patients with bicuspid aortic valve stenosis have not been studied in a large scale …

Adolescent and Young Adult (AYA) Oncology, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology

…, KC Oeffinger, CA Pratilas, D Reed, J Skiles… - Journal of the National …, 2023 - jnccn.org
This selection from the NCCN Guidelines for Adolescent and Young Adult (AYA) Oncology
focuses on considerations for the comprehensive care of AYA patients with cancer …

[HTML][HTML] End-of-life experiences in adolescents dying with cancer

CJ Bell, J Skiles, K Pradhan, VL Champion - Supportive care in cancer, 2010 - Springer
Purpose This study explores the experiences of individuals in early, middle, and late
adolescence dying from cancer. Place of death, medications used at end of life (EOL), and …