User profiles for "author:J R Mann"

Jeffrey R Mann

Melbourne
Verified email at monash.edu
Cited by 10093

Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention

AJ Dannenberg, SM Lippman, JR Mann… - Journal of clinical …, 2005 - ascopubs.org
Understanding the mechanisms underlying carcinogenesis provides insights that are
necessary for the development of therapeutic strategies to prevent cancer …

The role of prostaglandins and other eicosanoids in the gastrointestinal tract

D Wang, JR Mann, RN Dubois - Gastroenterology, 2005 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) are generally prescribed to ameliorate
symptoms associated with acute pain and chronic inflammatory diseases such as arthritis …

Mechanisms of disease: Inflammatory mediators and cancer prevention

JR Mann, MG Backlund, RN DuBois - Nature clinical practice Oncology, 2005 - nature.com
Discovery of molecular pathways critical to carcinogenesis is revolutionizing the treatment
and prevention of cancer. Traditional chemotherapeutic approaches usually cause'global' …

Prevalence and Diversity of Constitutional Mutations in the p53 Gene among 21 Li-Fraumeni Families

JM Birch, AL Hartley, KJ Tricker, J Prosser, A Condie… - Cancer research, 1994 - AACR
The entire coding sequence of the p53 gene was analysed for the presence of mutations in
12 families conforming to a restricted definition of Li-Fraumeni syndrome (classic LFS) and …

ATRX interacts with H3. 3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

LH Wong, JD McGhie, M Sim, MA Anderson… - Genome …, 2010 - genome.cshlp.org
ATRX (a lpha t halassemia/mental r etardation syndrome X-linked) belongs to the
SWI2/SNF2 family of chromatin remodeling proteins. Besides the ATPase/helicase domain …

Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice

C Mulle, A Sailer, I Pérez-Otaño, H Dickinson-Anson… - Nature, 1998 - nature.com
Abstract l-glutamate, the neurotransmitter of the majority of excitatory synapses in the brain,
acts on three classes of ionotropic receptors: NMDA (N-methyl-d-aspartate), AMPA (α-amino …

[PDF][PDF] RNA binding antagonizes neurotoxic phase transitions of TDP-43

JR Mann, AM Gleixner, JC Mauna, E Gomes… - Neuron, 2019 - cell.com
TDP-43 proteinopathy is a pathological hallmark of amyotrophic lateral sclerosis and
frontotemporal dementia where cytoplasmic TDP-43 inclusions are observed within …

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

LM Cree, DC Samuels, SC de Sousa Lopes… - Nature …, 2008 - nature.com
Mammalian mitochondrial DNA (mtDNA) is inherited principally down the maternal line, but
the mechanisms involved are not fully understood. Females harboring a mixture of mutant …

[HTML][HTML] Inner ear defects induced by null mutationof the isk Gene

DE Vetter, JR Mann, P Wangemann, J Liu… - Neuron, 1996 - cell.com
The isk gene is expressed in many tissues. Pharmacological evidence from the inner ear
suggests that Isk mediates potassium secretion into the endolymph. To examine the …

[HTML][HTML] 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer

MG Backlund, JR Mann, VR Holla, FG Buchanan… - Journal of Biological …, 2005 - ASBMB
Prostaglandin E 2 (PGE 2) can stimulate tumor progression by modulating several
proneoplastic pathways, including proliferation, angiogenesis, cell migration, invasion, and …