Leukotrienes have physiological roles in innate immune responses and pathological roles in
inflammatory diseases, such as asthma, allergic rhinitis and atherosclerosis. Anti-leukotriene …

Background and purpose: The aim of this study was to assess the potential of an antagonist
selective for the lysophosphatidic acid receptor, LPA1, in treating lung fibrosis We evaluated …

Prostaglandin D2 (PGD2) is one of a family of biologically active lipids derived from
arachidonic acid via the action of COX-1 and COX-2. PGD2 is released from mast cells and …

Lysophosphatidic acid (LPA) is a bioactive phospholipid that signals through a family of at
least six G protein-coupled receptors designated LPA1–6. LPA type 1 receptor (LPA1) …

3-(S)-Pyrimidin-5-yl-9-(5, 6, 7, 8-tetrahydro-[1, 8] naphthyridin-2-yl)-nonanoic acid (5e) and 3-
(S)-(methylpyrimidin-5-yl)-9-(5, 6, 7, 8-tetrahydro-[1, 8] naphthyridin-2-yl)-nonanoic acid (5f) …

Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine to
lysophosphatidic acid (LPA). LPA is a bioactive phospholipid that regulates diverse …

LOXL2 catalyzes the oxidative deamination of ε-amines of lysine and hydroxylysine residues
within collagen and elastin, generating reactive aldehydes (allysine). Condensation with …

Two series of novel LOXL2 enzyme inhibitors are described: benzylamines substituted with
electron withdrawing groups at the para-position and 2-substituted pyridine-4 …

Autotaxin (ATX) is a secreted glycoprotein that converts lysophosphatidylcholine (LPC) to
the bioactive phospholipid lysophosphatidic acid (LPA) and is the major enzyme generating …

3 (S)-(6-Methoxypyridin-3-yl)-3-{2-oxo-3-[3-(5, 6, 7, 8-tetrahydro-[1, 8]-naphthyridin-2-yl)
propyl] imidazolidin-1-yl} propionic acid 6 was identified as a potent and selective antagonist …