Oral contraceptives: are drug interactions of clinical significance?

GM Shenfield - Drug Safety, 1993 - Springer
There is a large quantity of literature on drug interactions with oral contraceptive (OC)
steroids although their incidence is not known. The potential clinical significance of some …

[HTML][HTML] Genetic polymorphisms, drug metabolism and drug concentrations

GM Shenfield - The Clinical Biochemist Reviews, 2004 - ncbi.nlm.nih.gov
The interfaces between genetics and drug metabolism have recently been the subjects of
intense research activity. Pharmacogenomics uses molecular biological techniques to study …

Influence of thyroid dysfunction on drug pharmacokinetics

GM Shenfield - Clinical Pharmacokinetics, 1981 - Springer
When thyroid function is altered there are a series of physiological changes which are likely
to affect drug absorption, metabolism or excretion, and altered pharmacokinetics have been …

Drug combinations and impaired renal function–the 'triple whammy'

KK Loboz, GM Shenfield - British journal of clinical …, 2005 - Wiley Online Library
Background Recent studies have identified the 'triple whammy'in which combinations of
diuretics, nonsteroidal anti‐inflammatory drugs (NSAIDs), ACE inhibitors (ACEI) and/or …

Functional ability of patients to manage medication packaging: a survey of geriatric inpatients

PA Atkin, TP Finnegan, SJ Ogle… - Age and ageing, 1994 - academic.oup.com
This study measured the prevalence of difficulty experienced by elderly inpatients in
opening and removing tablets from a range of common commercial medication packagings …

Survey of the use of complementary medicines and therapies in children with asthma

G Shenfield, E Lim, H Allen - Journal of paediatrics and child …, 2002 - Wiley Online Library
Objective: To survey the frequency of use of complementary medicines (CM) and
complementary therapies (CT) in asthmatic children. Methodology: A 3‐month survey of …

Pregnancy attributable to interaction between tetracycline and oral contraceptives.

JF Bacon, GM Shenfield - British Medical Journal, 1980 - ncbi.nlm.nih.gov
Various drugs, including antibiotics, may cause failure of contraception and breakthrough
bleeding in patients on oral contraceptives.'Early reports implicated rifampicin,'which was …

Optimizing the use of antithrombotic therapy for atrial fibrillation in older people: a pharmacist‐led multidisciplinary intervention

BV Bajorek, I Krass, SJ Ogle, MJ Duguid… - Journal of the …, 2005 - Wiley Online Library
Objectives: To develop, implement, and evaluate a pharmacist‐led multidisciplinary
intervention in a hospital setting that would optimize antithrombotic use in elderly atrial …

Adrenal suppression following extradural steroids

S Jacobs, PT Pullan, JM POTTER, GM Shenfield - Anaesthesia, 1983 - Wiley Online Library
Adrenocortical function was tested in 12 patients following a single lumbar extradural
injection ofmethyl‐prednisolone acetate ('Depo‐Medrol') 80 mg as treatment for chronic …

Amelioration of experimental cisplatin and paclitaxel neuropathy with glutamate

FM Boyle, HR Wheeler, GM Shenfield - Journal of neuro-oncology, 1999 - Springer
A major toxic effect of the chemotherapeutic agents paclitaxel and cisplatin is peripheral
neuropathy. We report the use of a rat model of cytotoxic neuropathy to evaluate the role of …