Hepatotoxicity remains a significant cause for drug failures during clinical trials. This is due,
in part, to the idiosyncratic nature of toxicity in humans and inherent physiological …

Preventing infection during primary immunodeficiency (PID) can include antimicrobial
agents, immunotherapy, and immunization, depending on the type of PID. Observation is …

Background Experimental and clinical evidence suggests that cyclosporine may attenuate
reperfusion injury and reduce myocardial infarct size. We aimed to test whether cyclosporine …

Fluoroquinolones are an important group of antibiotics widely used in adult patients
because of their excellent tissue penetration and their bactericidal activity. They are not …

Hydrogen sulfide (H2S) is an important brain, lung, and nose toxicant. Inhibition of
cytochrome oxidase is the primary biochemical effect associated with lethal H2S exposure …

Background A recent increase in children admitted with hypotensive shock and fever in the
context of the COVID-19 outbreak requires an urgent characterization and assessment of the …

Objectives The aim of this study was to describe severe forms of novel coronavirus disease
2019 in children, including patient characteristics, clinical, laboratory, and imaging findings …

Background. Procalcitonin (PCT) concentration increases in bacterial infections but remains
low in viral infections and inflammatory diseases. The change is rapid and the molecule is …

AIMS To assess the sensitivity, specificity, and predictive value of procalcitonin (PCT) in
differentiating bacterial and viral causes of pneumonia. METHODS A total of 72 children with …

We measured the plasma procalcitonin levels in 59 children who were admitted to the
hospital because of bacterial or viral meningitis. Eighteen children with acute bacterial …