Background Cystic fibrosis is a lethal inherited disease that affects multiple organs. To
provide optimal pharmacological treatment of comorbidities associated with cystic fibrosis …

Desmopressin is a synthetic analogue of the natural antidiuretic hormone arginine
vasopressin. Over the years, it has been clinically used to manage nocturnal polyuria in …

Pediatric drug research is still substandard, not reaching the same quality level as adult drug
research. Despite the efforts made by the Food and Drug Administration and European …

Background Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a novel
method to treat patients with peritoneal metastases (PM). We aimed to study the tolerability …

The aim of this study was to determine the toxicokinetic characteristics of ZEN and its
modified forms, α-zearalenol (α-ZEL), β-zearalenol (β-ZEL), zearalenone-14-glucoside …

Because peritoneal metastasis (PM) from ovarian cancer is characterized by non-specific
symptoms, it is often diagnosed at advanced stages. Pressurized intraperitoneal aerosol …

Since the implementation of several legislations to improve pediatric drug research, more
pediatric clinical trials are being performed. In order to optimize these pediatric trials …

The volume of distribution at steady state (Vss) in neonates is still often estimated through
isometric scaling from adult values, disregarding developmental changes beyond body …

Pediatric drug development, especially in disease areas that only affect children, can be
stimulated by using juvenile animal models not only for general safety studies, but also to …

The kidneys play an important role in many processes, including urine formation, water
conservation, acid-base equilibrium, and elimination of waste. The anatomic and functional …