Ovarian failure following abdominal irradiation in childhood: natural history and prognosis

WHB Wallace, SM Shalet, EC Crowne… - Clinical oncology, 1989 - Elsevier
Ovarian function has been reviewed sequentially since 1975 in 53 patients treated in
childhood between 1942 and 1985 for an intra-abdominal tumour with surgery and external …

[HTML][HTML] Obesity-Associated GNAS Mutations and the Melanocortin Pathway

E Mendes de Oliveira, JM Keogh, F Talbot… - … England Journal of …, 2021 - Mass Medical Soc
Background GNAS encodes the Gαs (stimulatory G-protein alpha subunit) protein, which
mediates G protein–coupled receptor (GPCR) signaling. GNAS mutations cause …

Which factors are associated with a successful outcome in a weight management programme for obese children?

MA Sabin, A Ford, L Hunt, R Jamal… - Journal of evaluation …, 2007 - Wiley Online Library
Aims and objective To identify factors important in determining whether an obese child
achieves significant reductions in Body Mass Index Standard Deviation Score (BMI SDS) …

Novel mutations of the growth hormone 1 (GH1) gene disclosed by modulation of the clinical selection criteria for individuals with short stature

DS Millar, MD Lewis, M Horan, V Newsway… - Human …, 2003 - Wiley Online Library
Subtle mutations in the growth hormone 1 (GH1) gene have been regarded as a
comparatively rare cause of short stature. Such lesions were sought in a group of 41 …

Reduced insulin sensitivity in childhood survivors of haematopoietic stem cell transplantation is associated with lipodystropic and sarcopenic phenotypes

C Wei, MS Thyagiarajan, LP Hunt… - Pediatric blood & …, 2015 - Wiley Online Library
Background Survivors of childhood acute lymphoblastic leukaemia (ALL) treated with
haematopoietic stem cell transplantation and total body irradiation (HSCT/TBI) have a high …

Genetic analysis of pediatric primary adrenal insufficiency of unknown etiology: 25 years' experience in the UK

F Buonocore, A Maharaj, Y Qamar… - Journal of the …, 2021 - academic.oup.com
Context Although primary adrenal insufficiency (PAI) in children and young people is often
due to congenital adrenal hyperplasia (CAH) or autoimmunity, other genetic causes occur …

Clinical measures of adiposity and percentage fat loss: which measure most accurately reflects fat loss and what should we aim for?

LP Hunt, A Ford, MA Sabin, EC Crowne… - Archives of Disease in …, 2007 - adc.bmj.com
Objective: To determine which clinical measure of childhood obesity should be monitored to
best reflect change in adiposity in a weight management programme and estimate the …

Counterregulation during spontaneous nocturnal hypoglycemia in prepubertal children with type 1 diabetes.

KA Matyka, EC Crowne, PJ Havel… - Diabetes …, 1999 - Am Diabetes Assoc
OBJECTIVE: To examine counterregulatory responses during spontaneous nocturnal
hypoglycemia in prepubertal children with type 1 diabetes. RESEARCH DESIGN AND …

Fatty acid‐induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of …

MA Sabin, CEH Stewart, EC Crowne… - Journal of cellular …, 2007 - Wiley Online Library
The elevation of free fatty acids (FFAs), observed in childhood obesity results in
intramyocellular lipid (IMCL) accumulation with consequent insulin resistance. Using in vitro …

[HTML][HTML] The hypothalamic–pituitary–adrenal axis in childhood cancer survivors

C Wei, EC Crowne - Endocrine-Related Cancer, 2018 - erc.bioscientifica.com
Endocrine abnormalities are common among childhood cancer survivors. Abnormalities of
the hypothalamic–pituitary–adrenal axis (HPAA) are relatively less common, but the …