[HTML][HTML] Variation in antibiotic prescription rates in febrile children presenting to emergency departments across Europe (MOFICHE): a multicentre observational study

NN Hagedoorn, DM Borensztajn, R Nijman… - PLoS …, 2020 - journals.plos.org
Background The prescription rate of antibiotics is high for febrile children visiting the
emergency department (ED), contributing to antimicrobial resistance. Large studies at …

[HTML][HTML] Relationship between molecular pathogen detection and clinical disease in febrile children across Europe: a multicentre, prospective observational study

P Shah, M Voice, L Calvo-Bado… - The Lancet Regional …, 2023 - thelancet.com
Background The PERFORM study aimed to understand causes of febrile childhood illness
by comparing molecular pathogen detection with current clinical practice. Methods Febrile …

[HTML][HTML] A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children …

HR Jackson, J Zandstra, S Menikou… - The Lancet Digital …, 2023 - thelancet.com
Background Differentiating between self-resolving viral infections and bacterial infections in
children who are febrile is a common challenge, causing difficulties in identifying which …

[HTML][HTML] Variation in hospital admission in febrile children evaluated at the Emergency Department (ED) in Europe: PERFORM, a multicentre prospective observational …

DM Borensztajn, NN Hagedoorn, I Rivero Calle… - PLoS …, 2021 - journals.plos.org
Objectives Hospitalisation is frequently used as a marker of disease severity in
observational Emergency Department (ED) studies. The comparison of ED admission rates …

Rapid viral testing and antibiotic prescription in febrile children with respiratory symptoms visiting emergency departments in Europe

CD Tan, NN Hagedoorn, JE Dewez… - The Pediatric …, 2022 - journals.lww.com
Background. Inappropriate antibiotic prescribing often occurs in children with self-limiting
respiratory tract infections, contributing to antimicrobial resistance. It has been suggested …

Sex-specific differences in children attending the emergency department: prospective observational study

JM Zachariasse, DM Borensztajn, D Nieboer… - BMJ open, 2020 - bmjopen.bmj.com
Objective To assess the role of sex in the presentation and management of children
attending the emergency department (ED). Design The TrIAGE project (TRiage …

[HTML][HTML] Febrile children with comorbidities at the emergency department—a multicentre observational study

DM Borensztajn, NN Hagedoorn, ED Carrol… - European journal of …, 2022 - Springer
We aimed to describe characteristics and management of children with comorbidities
attending European emergency departments (EDs) with fever. MOFICHE (Management and …

[PDF][PDF] Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens

E Willems, J Gloerich, A Suppers, M van der Flier… - Iscience, 2023 - cell.com
Mechanisms of infection and pathogenesis have predominantly been studied based on
differential gene or protein expression. Less is known about posttranslational modifications …

Parents' experiences with a sick or injured child during the COVID-19 lockdown: an online survey in the Netherlands

CD Tan, EK Lutgert, S Neill, R Carter, RB Jones… - BMJ open, 2021 - bmjopen.bmj.com
Objective To assess the impact of the COVID-19 lockdown on parents' health-seeking
behaviour and care for a sick or injured child in the Netherlands. Design and setting An …

Improving triage for children with comorbidity using the ED-PEWS: an observational study

JM Zachariasse, PR Espina, DM Borensztajn… - Archives of Disease in …, 2022 - adc.bmj.com
Objective To assess the value of the Emergency Department–Pediatric Early Warning Score
(ED-PEWS) for triage of children with comorbidity. Design Secondary analysis of a …