Many patients with chronic pain do not obtain adequate relief or experience unacceptable
side effects from existing treatments. Moreover, even when clinical trials report positive …

Abstract The current International Association for the Study of Pain (IASP) definition of pain
as “An unpleasant sensory and emotional experience associated with actual or potential …

Objective. To provide recommendations for the core outcome domains that should be
considered by investigators conducting clinical trials of the efficacy and effectiveness of …

Background In early life, the innate immune system can recognize both viable and nonviable
parts of microorganisms. Immune activation may direct the immune response, thus …

Aims/hypothesis Increased intra-abdominal fat is associated with insulin resistance and an
atherogenic lipoprotein profile. Circulating concentrations of adiponectin, an adipocyte …

Background A farming environment protects against development of asthma, hay fever, and
atopic sensitisation in children. We aimed to establish whether increased exposure to …

The vast majority of bereavement research is conducted after a loss has occurred. Thus,
knowledge of the divergent trajectories of grieving or their antecedent predictors is lacking …

" For description and defense of the narrative configurations of everyday life, and of the
practical and social character of those narratives, there is no better treatment than Time …

The underlying pathophysiology of the metabolic syndrome is the subject of debate, with
both insulin resistance and obesity considered as important factors. We evaluated the …

The industrial-organization (IO) approach to international trade (“new trade theory”) has
incorporated features of increasing returns to scale, imperfect competition, and product …