Animal models for SARS‐CoV‐2 research: a comprehensive literature review
Emerging and re‐emerging viral diseases can create devastating effects on human lives
and may also lead to economic crises. The ongoing COVID‐19 pandemic due to the novel …
and may also lead to economic crises. The ongoing COVID‐19 pandemic due to the novel …
[HTML][HTML] Frequency and clinical utility of olfactory dysfunction in COVID-19: a systematic review and meta-analysis
KW Pang, J Chee, S Subramaniam, CL Ng - Current allergy and asthma …, 2020 - Springer
Background Olfactory dysfunction (OD) has been gaining recognition as a symptom of
COVID-19, but its clinical utility has not been well defined. Objectives To quantify the clinical …
COVID-19, but its clinical utility has not been well defined. Objectives To quantify the clinical …
[HTML][HTML] Immuno-epidemiology and pathophysiology of coronavirus disease 2019 (COVID-19)
Occasional zoonotic viral attacks on immunologically naive populations result in massive
death tolls that are capable of threatening human survival. Currently, severe acute …
death tolls that are capable of threatening human survival. Currently, severe acute …
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
MA Phillips, J Lotharius, K Marsh, J White… - Science translational …, 2015 - science.org
Malaria is one of the most significant causes of childhood mortality, but disease control
efforts are threatened by resistance of the Plasmodium parasite to current therapies …
efforts are threatened by resistance of the Plasmodium parasite to current therapies …
Monitoring temperature effect on a long suspension bridge
YL Xu, B Chen, CL Ng, KY Wong… - structural control and …, 2010 - Wiley Online Library
Abstract The Tsing Ma Bridge in Hong Kong is a long suspension bridge. A wind and
structural health monitoring system (WASHMS) has been installed in the bridge and …
structural health monitoring system (WASHMS) has been installed in the bridge and …
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin
Aminoglycosides are potent antibacterials, but therapy is compromised by substantial
toxicity causing, in particular, irreversible hearing loss. Aminoglycoside ototoxicity occurs …
toxicity causing, in particular, irreversible hearing loss. Aminoglycoside ototoxicity occurs …
[HTML][HTML] Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate
A central problem in biology is to identify gene function. One approach is to infer function in
large supergenomic networks of interactions and ancestral relationships among genes; …
large supergenomic networks of interactions and ancestral relationships among genes; …
Unusual base pairing during the decoding of a stop codon by the ribosome
IS Fernández, CL Ng, AC Kelley, G Wu, YT Yu… - Nature, 2013 - nature.com
During normal translation, the binding of a release factor to one of the three stop codons
(UGA, UAA or UAG) results in the termination of protein synthesis. However, modification of …
(UGA, UAA or UAG) results in the termination of protein synthesis. However, modification of …
[HTML][HTML] A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
Benzoxaboroles are effective against bacterial, fungal and protozoan pathogens. We report
potent activity of the benzoxaborole AN3661 against Plasmodium falciparum laboratory …
potent activity of the benzoxaborole AN3661 against Plasmodium falciparum laboratory …
[HTML][HTML] Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study
JS McCarthy, J Lotharius, T Rückle… - The Lancet Infectious …, 2017 - thelancet.com
Background DSM265 is a novel antimalarial that inhibits plasmodial dihydroorotate
dehydrogenase, an enzyme essential for pyrimidine biosynthesis. We investigated the …
dehydrogenase, an enzyme essential for pyrimidine biosynthesis. We investigated the …