User profiles for "author:C J Roberts"

Christopher J. Roberts

University of Delaware
Verified email at udel.edu
Cited by 7657

Surface plasmon resonance analysis of dynamic biological interactions with biomaterials

RJ Green, RA Frazier, KM Shakesheff, MC Davies… - Biomaterials, 2000 - Elsevier
Surface plasmon resonance (SPR) is an optical technique that is widely gaining recognition
as a valuable tool to investigate biological interactions. SPR offers real time in situ analysis …

Integrating genetic approaches into the discovery of anticancer drugs

LH Hartwell, P Szankasi, CJ Roberts, AW Murray… - Science, 1997 - science.org
The discovery of anticancer drugs is now driven by the numerous molecular alterations
identified in tumor cells over the past decade. To exploit these alterations, it is necessary to …

Therapeutic protein aggregation: mechanisms, design, and control

CJ Roberts - Trends in biotechnology, 2014 - cell.com
Although it is well known that proteins are only marginally stable in their folded states, it is
often less well appreciated that most proteins are inherently aggregation-prone in their …

Functional profiling of the Saccharomyces cerevisiae genome

G Giaever, AM Chu, L Ni, C Connelly, L Riles… - nature, 2002 - nature.com
Determining the effect of gene deletion is a fundamental approach to understanding gene
function. Conventional genetic screens exhibit biases, and genes contributing to a …

Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

EA Winzeler, DD Shoemaker, A Astromoff, H Liang… - science, 1999 - science.org
The functions of many open reading frames (ORFs) identified in genome-sequencing
projects are unknown. New, whole-genome approaches are required to systematically …

[HTML][HTML] Functional discovery via a compendium of expression profiles

TR Hughes, MJ Marton, AR Jones, CJ Roberts… - Cell, 2000 - cell.com
Ascertaining the impact of uncharacterized perturbations on the cell is a fundamental
problem in biology. Here, we describe how a single assay can be used to monitor hundreds …

Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles

CJ Roberts, B Nelson, MJ Marton, R Stoughton… - Science, 2000 - science.org
Genome-wide transcript profiling was used to monitor signal transduction during yeast
pheromone response. Genetic manipulations allowed analysis of changes in gene …

Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate

A Carlsbecker, JY Lee, CJ Roberts, J Dettmer… - Nature, 2010 - nature.com
A key question in developmental biology is how cells exchange positional information for
proper patterning during organ development. In plant roots the radial tissue organization is …

[HTML][HTML] Exploration of essential gene functions via titratable promoter alleles

S Mnaimneh, AP Davierwala, J Haynes, J Moffat… - Cell, 2004 - cell.com
Nearly 20% of yeast genes are required for viability, hindering genetic analysis with
knockouts. We created promoter-shutoff strains for over two-thirds of all essential yeast …

Influence of corneal biomechanical properties on intraocular pressure measurement: quantitative analysis

J Liu, CJ Roberts - Journal of Cataract & Refractive Surgery, 2005 - journals.lww.com
Purpose: To understand and quantify intraocular pressure (IOP) measurement errors
introduced by corneal variables during applanation tonometry using a cornea …