User profiles for "author:C J Roberts"
Christopher J. RobertsUniversity of Delaware Verified email at udel.edu Cited by 7657 |
Surface plasmon resonance analysis of dynamic biological interactions with biomaterials
Surface plasmon resonance (SPR) is an optical technique that is widely gaining recognition
as a valuable tool to investigate biological interactions. SPR offers real time in situ analysis …
as a valuable tool to investigate biological interactions. SPR offers real time in situ analysis …
Integrating genetic approaches into the discovery of anticancer drugs
LH Hartwell, P Szankasi, CJ Roberts, AW Murray… - Science, 1997 - science.org
The discovery of anticancer drugs is now driven by the numerous molecular alterations
identified in tumor cells over the past decade. To exploit these alterations, it is necessary to …
identified in tumor cells over the past decade. To exploit these alterations, it is necessary to …
Therapeutic protein aggregation: mechanisms, design, and control
CJ Roberts - Trends in biotechnology, 2014 - cell.com
Although it is well known that proteins are only marginally stable in their folded states, it is
often less well appreciated that most proteins are inherently aggregation-prone in their …
often less well appreciated that most proteins are inherently aggregation-prone in their …
Functional profiling of the Saccharomyces cerevisiae genome
Determining the effect of gene deletion is a fundamental approach to understanding gene
function. Conventional genetic screens exhibit biases, and genes contributing to a …
function. Conventional genetic screens exhibit biases, and genes contributing to a …
Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis
EA Winzeler, DD Shoemaker, A Astromoff, H Liang… - science, 1999 - science.org
The functions of many open reading frames (ORFs) identified in genome-sequencing
projects are unknown. New, whole-genome approaches are required to systematically …
projects are unknown. New, whole-genome approaches are required to systematically …
[HTML][HTML] Functional discovery via a compendium of expression profiles
TR Hughes, MJ Marton, AR Jones, CJ Roberts… - Cell, 2000 - cell.com
Ascertaining the impact of uncharacterized perturbations on the cell is a fundamental
problem in biology. Here, we describe how a single assay can be used to monitor hundreds …
problem in biology. Here, we describe how a single assay can be used to monitor hundreds …
Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles
CJ Roberts, B Nelson, MJ Marton, R Stoughton… - Science, 2000 - science.org
Genome-wide transcript profiling was used to monitor signal transduction during yeast
pheromone response. Genetic manipulations allowed analysis of changes in gene …
pheromone response. Genetic manipulations allowed analysis of changes in gene …
Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate
A Carlsbecker, JY Lee, CJ Roberts, J Dettmer… - Nature, 2010 - nature.com
A key question in developmental biology is how cells exchange positional information for
proper patterning during organ development. In plant roots the radial tissue organization is …
proper patterning during organ development. In plant roots the radial tissue organization is …
[HTML][HTML] Exploration of essential gene functions via titratable promoter alleles
Nearly 20% of yeast genes are required for viability, hindering genetic analysis with
knockouts. We created promoter-shutoff strains for over two-thirds of all essential yeast …
knockouts. We created promoter-shutoff strains for over two-thirds of all essential yeast …
Influence of corneal biomechanical properties on intraocular pressure measurement: quantitative analysis
J Liu, CJ Roberts - Journal of Cataract & Refractive Surgery, 2005 - journals.lww.com
Purpose: To understand and quantify intraocular pressure (IOP) measurement errors
introduced by corneal variables during applanation tonometry using a cornea …
introduced by corneal variables during applanation tonometry using a cornea …