Data-intensive research depends on tools that manage multidimensional, heterogeneous
datasets. We built OME Remote Objects (OMERO), a software platform that enables access …

The mature thymic epithelium is complex, with two major compartments—the cortex and the
medulla—each containing several functionally distinct epithelial-cell types. There is …

Aging is associated with decreased immune function that leads to increased morbidity and
mortality in the elderly. Immune senescence is accompanied by age-related changes in two …

Elucidating the mechanisms underlying hematopoietic stem cell (HSC) specification and
expansion in the embryo has been hampered by the lack of analytical cell culture systems …

1. The responses of neurons in the anteroventral cochlear nucleus (AVCN) of barbiturate-
anesthetized cats are characterized with regard to features of their responses to short tone …

A three-component condensation reaction between 2-aminopyridine, an aldehyde and an
isonitrile catalyzed by scandium triflate affords derivatives of 3-aminoimidazo [1, 2-a] …

T cell differentiation and repertoire selection depend critically on several distinct thymic
epithelial cell types, whose lineage relationships are unclear. We have investigated these …

The nude mutation (nu) causes athymia and hairlessness, but the molecular mechanisms by
which it acts have not been determined. To address the role of nu in thymogenesis, we …

The thymus and parathyroids originate from a common primordium that develops from the
third pharyngeal pouch in mice and humans. The molecular mechanism that specifies this …

For many cancer types, incidence rises rapidly with age as an apparent power law,
supporting the idea that cancer is caused by a gradual accumulation of genetic mutations …