Some new, simple and efficient stereological methods and their use in pathological research and diagnosis

…, A Møller, K Nielsen, JR Nyengaard, B Pakkenberg… - Apmis, 1988 - Wiley Online Library
Stereology is a set of simple and efficient methods for quantitation of three‐dimensional
microscopic structures which is specifically tuned to provide reliable data from sections …

The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis

…, A Møller, K Nielsen, JR Nyengaard, B Pakkenberg… - Apmis, 1988 - Wiley Online Library
The new stereological methods for correct and efficient sampling and sizing of cells and
other particles are reviewed. There is a hierarchy of methods starting from the simplest …

Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: review and recommendations of the COSBID research group

…, G Bohner, E Rostrup, B Pakkenberg… - Journal of Cerebral …, 2017 - journals.sagepub.com
Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal
transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable …

Neocortical neuron number in humans: effect of sex and age

B Pakkenberg, HJG Gundersen - Journal of comparative …, 1997 - Wiley Online Library
Modern stereological methods provide precise and reliable estimates of the number of
neurons in specific regions of the brain. We decided to estimate the total number of …

Neocortical glial cell numbers in human brains

DP Pelvig, H Pakkenberg, AK Stark, B Pakkenberg - Neurobiology of aging, 2008 - Elsevier
Stereological cell counting was applied to post-mortem neocortices of human brains from 31
normal individuals, age 18–93 years, 18 females (average age 65 years, range 18–93) and …

Marked loss of myelinated nerve fibers in the human brain with age

…, Y Tang, B Pakkenberg - Journal of comparative …, 2003 - Wiley Online Library
The white matter is the structure of the brain that declines most with age—almost 30%, but
little is known about the age‐effect on the fibers that constitute the white matter. In the …

Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics

B Pakkenberg - Archives of general psychiatry, 1990 - jamanetwork.com
• Using a new and unbiased stereological technique, the total numbers of neuron and glial
cells in the mediodorsal thalamic nucleus and the nucleus accumbens were found to be …

Age-induced white matter changes in the human brain: a stereological investigation

Y Tang, JR Nyengaard, B Pakkenberg… - Neurobiology of …, 1997 - Elsevier
In the present pilot study, age-related white matter changes were investigated by the use of
design-based stereological methods. In the brains of elderly subjects, the total volume of the …

Aging and the human neocortex

B Pakkenberg, D Pelvig, L Marner, MJ Bundgaard… - Experimental …, 2003 - Elsevier
Neurostereology has been applied to quantitative anatomical study of the human brain.
Such studies have included the total neocortical number of neurons and glial cells, the …

Total number of neurons and glial cells in human brain nuclei estimated by the disector and the fractionator

B Pakkenberg, HJG Gundersen - Journal of microscopy, 1988 - Wiley Online Library
Unbiased estimates of the total number of neurons and glial cells from central regions of
grey matter in human brains are obtained using the disector principle in modifications which …